Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
| العنوان: | Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human |
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| المؤلفون: | Fang Chen, Hai-Yan Pan, Lian-Cheng Lei, Wei-Zhong He, Hua Xiang, Peng-Zhe Qin, Biao Di, Xiao-Jing Yu, Chun-Ming Pan, Hui-Ming Luo, Ling-Hui Li, Ye-Dong Yu, Duan-Hua Zhou, Hui Li, Xiangang Kong, Ling Fang, Hua-Jun Zheng, Kui Zheng, Guoping Zhao, Jian-Feng He, Huai-Dong Song, Yu-Wei Gao, Huan-Ying Zheng, Larry J. Anderson, Hui-Qiong Zhou, Zong-Ming Guo, Qiu-Xia Chen, Feng Cheng, Neri Niccolai, Jean-Claude Manuguerra, Wen-Jia Liang, Yang Gao, Rui-Heng Xu, Hua Xuan, Xin-Wei Wu, Pei Hao, Hua Tang, Ming Liao, Chung-I Wu, Ottavia Spiga, Sai-Juan Chen, Arnaud Fontanet, Suxiang Tong, Yu-Fei Liu, Antoine Danchin, Jin-Ding Chen, Shur-Wern Wang Chern, Yixue Li, Jin-Yan Lin, Li-Juan He, Andrea Bernini, Shengyue Wang, Lin Du, Yu-Qi Ren, Guodong Liang, Li-Yun Jiang, Ming Wang, Chang-Chun Tu, Guo-Wei Zhang |
| المساهمون: | Plazi, State Key Laboratory of Virology, Wuhan University [China], Institut Pasteur [Paris] (IP) |
| المصدر: | Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (7), pp.2430-2435. ⟨10.1073/pnas.0409608102⟩ |
| بيانات النشر: | Zenodo, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Nonsynonymous substitution, China, Genes, Viral, Coronaviridae, [SDV]Life Sciences [q-bio], Severe Acute Respiratory Syndrome, medicine.disease_cause, Polymorphism, Single Nucleotide, Disease Outbreaks, virus-host, Evolution, Molecular, Species Specificity, Viral Envelope Proteins, Viverridae, pathogen-host, Zoonoses, biology.animal, Genetic variation, medicine, Animals, Humans, biotic relations, Viridae, Phylogeny, Coronavirus, Genetics, Membrane Glycoproteins, Multidisciplinary, biology, Phylogenetic tree, biotic associations, corona viruses, Outbreak, covid, pathogens, Biological Sciences, biology.organism_classification, biotic interaction, Virology, Amino Acid Substitution, Severe acute respiratory syndrome-related coronavirus, covid-19, Civet, Spike Glycoprotein, Coronavirus, Palm, CETAF-taskforce |
| الوصف: | The genomic sequences of severe acute respiratory syndrome coronaviruses from human and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly identical. Phylogenetic analysis suggested an independent viral invasion from animal to human in this new episode. Combining all existing data but excluding singletons, we identified 202 single-nucleotide variations. Among them, 17 are polymorphic in palm civets only. The ratio of nonsynonymous/synonymous nucleotide substitution in palm civets collected 1 yr apart from different geographic locations is very high, suggesting a rapid evolving process of viral proteins in civet as well, much like their adaptation in the human host in the early 2002–2003 epidemic. Major genetic variations in some critical genes, particularly the Spike gene, seemed essential for the transition from animal-to-human transmission to human-to-human transmission, which eventually caused the first severe acute respiratory syndrome outbreak of 2002/2003. |
| اللغة: | English |
| تدمد: | 0027-8424 1091-6490 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3711ffb56dd6ada2768557bb53b48710 https://zenodo.org/record/3949018 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3711ffb56dd6ada2768557bb53b48710 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 10916490 |
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