Plasma cholesterol and endogenous cholesterol synthesis during refeeding in anorexia nervosa
| العنوان: | Plasma cholesterol and endogenous cholesterol synthesis during refeeding in anorexia nervosa |
|---|---|
| المؤلفون: | Christine Feillet-Coudray, François Feillet, Jean-Marie Bard, Michel Vidailhet, Bernard Kabuth, Elisabeth Favre, H J Parra, Jean-Charles Fruchart |
| المساهمون: | ProdInra, Migration, Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA) |
| المصدر: | Clinica Chimica Acta Clinica Chimica Acta, Elsevier, 2000, 294, pp.45-56 |
| بيانات النشر: | Elsevier BV, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | medicine.medical_specialty, Anorexia Nervosa, Adolescent, Hydrocortisone, Apolipoprotein B, Diet therapy, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Population, Nutritional Status, Lathosterol, Biochemistry, Body Mass Index, Cholesterol, Dietary, Eating, chemistry.chemical_compound, Adrenocorticotropic Hormone, Internal medicine, Humans, Prealbumin, Medicine, Child, education, Serum Albumin, Triglycerides, education.field_of_study, Estradiol, biology, business.industry, Cholesterol, Body Weight, Biochemistry (medical), General Medicine, Metabolism, Body Height, [SDV] Life Sciences [q-bio], Hospitalization, Apolipoproteins, Endocrinology, chemistry, biology.protein, Female, lipids (amino acids, peptides, and proteins), business, Body mass index, Follow-Up Studies, Lipoprotein |
| الوصف: | Normal or high levels of cholesterol have been measured in patients with anorexia nervosa (AN). Given that cholesterol intake in AN is usually very low, the reasons for this anomaly are not clearly understood. We studied lipid and lipoprotein profiles and endogenous cholesterol synthesis, estimated by serum lathosterol, in a population of 14 girls with AN, before and during a period of 30 days refeeding. The initial body mass index (BMI) of the patients was 13.41±1.62 kg/m 2 . No changes were observed during refeeding in endocrine parameters (ACTH, cortisol and estradiol). At Day 0 the lipids data measured here showed normal levels of triglycerides, and total cholesterol at the upper limits of the normal range (5.44±1 mmol/l). At this time, total and LDL cholesterol were negatively correlated with transthyretin and BMI. Serum lathosterol (a precursor in cholesterol synthesis pathway) increased significantly (5.99±1.75 (Day 0) vs. 8.39±2.96 (Day 30); P =0.02) while there was a significant decrease in apo B (0.79±0.33 (Day 0) vs. 0.60±0.17 g/l (Day 30), P =0.02) with refeeding. Thus, patients with initial high cholesterol levels have the worst nutritional status and high cholesterol levels are not related to a de novo synthesis. This profile returns to normal with refeeding. An increase of cellular cholesterol uptake may be responsible for this apparently paradoxical evolution with increase of cholesterol synthesis and decrease of apo B during renutrition. |
| تدمد: | 0009-8981 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373b55b2cfce4eb38e03826cb22801d9 https://doi.org/10.1016/s0009-8981(99)00256-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....373b55b2cfce4eb38e03826cb22801d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00098981 |
|---|