Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice
| العنوان: | Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice |
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| المؤلفون: | Paul D. Acton, Niels Hellings, Jacobine Kuijlaars, Patrick De Haes, Steven Biesmans, Xavier Langlois, Nima Davoodi, Jan A. Bouwknecht, Theo Meert, Luc Ver Donck, Rony Nuydens, Liam J. R. Matthews |
| المصدر: | Mediators of Inflammation, Vol 2013 (2013) Mediators of Inflammation |
| بيانات النشر: | Hindawi Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, Sucrose, Luminescence, Lipopolysaccharide, Article Subject, Immunology, Inflammation, Mice, Transgenic, Biology, Choice Behavior, chemistry.chemical_compound, Mice, Immune system, medicine, lcsh:Pathology, Animals, Sickness behavior, Neuroinflammation, Illness Behavior, Neurons, Microglia, Behavior, Animal, Depression, Dentate gyrus, Calcium-Binding Proteins, Microfilament Proteins, Brain, Cell Biology, Feeding Behavior, Immunohistochemistry, Disease Models, Animal, medicine.anatomical_structure, chemistry, Astrocytes, Systemic administration, Cytokines, medicine.symptom, Research Article, lcsh:RB1-214 |
| الوصف: | Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1466-1861 0962-9351 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374672a9977bdd2a13b996e563263bec https://doaj.org/article/311938837c58467bba910192a119c888 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....374672a9977bdd2a13b996e563263bec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14661861 09629351 |
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