Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified T1-weighted steady-state cerebral blood volume approach
| العنوان: | Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified T1-weighted steady-state cerebral blood volume approach |
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| المؤلفون: | Freddy Ståhlberg, Jarl Risberg, Ronnie Wirestam, Elna-Marie Larsson, Lars Gustafson, Linda Knutsson, Siv Börjesson, Ulla Passant |
| المصدر: | Wirestam, R, Knutsson, L, Risberg, J, Börjesson, S, Larsson, E-M, Gustafson, L, Passant, U & Ståhlberg, F 2007, ' Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified T1-weighted steady-state cerebral blood volume approach. ', Acta Radiologica, vol. 48, no. 5, pp. 550-6 . |
| بيانات النشر: | SAGE Publications, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Steady state (electronics), Hemodynamics, Blood volume, Nuclear magnetic resonance, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Tomography, Emission-Computed, Single-Photon, Blood Volume, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, General Medicine, Blood flow, Middle Aged, Models, Theoretical, Magnetic Resonance Imaging, Cerebral blood flow, Cerebrovascular Circulation, Female, Tomography, business, Perfusion, Xenon Radioisotopes |
| الوصف: | Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state (ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and 133Xe SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K = CBV(ss)/CBV(DSC) was obtained for each individual. Average whole-brain CBF(DSC) was calculated, and the corrected MRI-based CBF estimate was given by CBF(ss) = K×CBF(DSC). Results: Average whole-brain SPECT CBF was 40.1±6.9 ml/min·100 g, while the corresponding uncorrected DSC-MRI-based value was 69.2±13.8 ml/min·100 g. After correction with the calibration factor, a CBF(ss) of 42.7±14.0 ml/min·100 g was obtained. The linear fit to CBF(ss)-versus-CBF(SPECT) data was close to proportionality ( R = 0.52). Conclusion: Calibration by steady-state CBV reduced the population average CBF to a reasonable level, and a modest linear correlation with the reference 133Xe SPECT technique was observed. Possible explanations for the limited accuracy are, for example, large-vessel partial-volume effects, low post-contrast signal enhancement in T1W images, and water-exchange effects. |
| تدمد: | 1600-0455 0284-1851 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374d857c4882837e42d3711bad7ef8bb https://doi.org/10.1080/02841850701280825 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....374d857c4882837e42d3711bad7ef8bb |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 16000455 02841851 |
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