Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine
| العنوان: | Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine |
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| المؤلفون: | Lisa Spirio, Kate O’Neill, Noriaki Matsuda, Melanie Fan, Eun Seok Gil, Sharanya Sankar, Florian Rebeca, Elton Aleksi, Marie Buffier, Maurice Bagot D’Arc |
| المصدر: | Frontiers in Bioengineering and Biotechnology, Vol 9 (2021) Frontiers in Bioengineering and Biotechnology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Histology, Biomedical Engineering, Bioengineering, Peptide, wound healing, Review, tissue regeneration, surgery, 03 medical and health sciences, 0302 clinical medicine, Interstitial fluid, self-assembling peptide hydrogel, endoscopy, nanofiber, Biomedicine, chemistry.chemical_classification, Hemostatic Agent, RADA16, business.industry, Bioengineering and Biotechnology, Biopharmaceutical, chemistry, 030220 oncology & carcinogenesis, Nanofiber, Self-healing hydrogels, hemostasis, 030211 gastroenterology & hepatology, business, Wound healing, TP248.13-248.65, Biomedical engineering, Biotechnology |
| الوصف: | RADA16 is a synthetic peptide that exists as a viscous solution in an acidic formulation. In an acidic aqueous environment, the peptides spontaneously self-assemble into β-sheet nanofibers. Upon exposure and buffering of RADA16 solution to the physiological pH of biological fluids such as blood, interstitial fluid and lymph, the nanofibers begin physically crosslinking within seconds into a stable interwoven transparent hydrogel 3-D matrix. The RADA16 nanofiber hydrogel structure closely resembles the 3-dimensional architecture of native extracellular matrices. These properties make RADA16 formulations ideal topical hemostatic agents for controlling bleeding during surgery and to prevent post-operative rebleeding. A commercial RADA16 formulation is currently used for hemostasis in cardiovascular, gastrointestinal, and otorhinolaryngological surgical procedures, and studies are underway to investigate its use in wound healing and adhesion reduction. Straightforward application of viscous RADA16 into areas that are not easily accessible circumvents technical challenges in difficult-to-reach bleeding sites. The transparent hydrogel allows clear visualization of the surgical field and facilitates suture line assessment and revision. The shear-thinning and thixotropic properties of RADA16 allow its easy application through a narrow nozzle such as an endoscopic catheter. RADA16 hydrogels can fill tissue voids and do not swell so can be safely used in close proximity to pressure-sensitive tissues and in enclosed non-expandable regions. By definition, the synthetic peptide avoids potential microbiological contamination and immune responses that may occur with animal-, plant-, or mineral-derived topical hemostats. In vitro experiments, animal studies, and recent clinical experiences suggest that RADA16 nanofibrous hydrogels can act as surrogate extracellular matrices that support cellular behavior and interactions essential for wound healing and for tissue regenerative applications. In the future, the unique nature of RADA16 may also allow us to use it as a depot for precisely regulated drug and biopharmaceutical delivery. |
| اللغة: | English |
| تدمد: | 2296-4185 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ef29ac6634214bbab5b465b1916e65 https://www.frontiersin.org/articles/10.3389/fbioe.2021.679525/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....37ef29ac6634214bbab5b465b1916e65 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22964185 |
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