A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
| العنوان: | A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy |
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| المؤلفون: | Can Huang, Jiaen Xie, Huaiyi Huang, Shuangling Luo, Pingyu Zhang, Qianling Zhang, Chao Liang |
| المصدر: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Porphyrins, Cancer therapy, Science, Ultrasonic Therapy, medicine.medical_treatment, General Physics and Astronomy, chemistry.chemical_element, Antineoplastic Agents, Photodynamic therapy, Tissue penetration, Article, Ruthenium, General Biochemistry, Genetics and Molecular Biology, Bioinorganic chemistry, Mice, chemistry.chemical_compound, In vivo, Neoplasms, medicine, Animals, Humans, Mice, Inbred BALB C, Multidisciplinary, Singlet Oxygen, Singlet oxygen, Sonodynamic therapy, food and beverages, General Chemistry, NAD, Combinatorial chemistry, humanities, Ultrasonic Waves, chemistry, Cancer cell, Phototoxicity, Oxidation-Reduction |
| الوصف: | As a basic structure of most polypyridinal metal complexes, [Ru(bpy)3]2+, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)3]2+ has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)3]2+ is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)3]2+ can produce singlet oxygen (1O2) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimulation in cancer cells. Furthermore, [Ru(bpy)3]2+ enables effective destruction of mice tumors, and the therapeutic effect can reach deep tissues over 10 cm under US irradiation. This work paves a way for polypyridinal metal complexes to be applied to the noninvasive precise sonotherapy of cancer. Sonodynamic therapy has therapeutic promise due to its safety and good tissue penetration, but is currently bottlenecked due to a lack of efficient and safe sonosensitizers. Here the authors show that [Ru(bpy)3]2+ can produce singlet oxygen and sonooxidize NADH in deep tissue, and destroy mouse tumors effectively. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384b66c84dec970c0da66dd99851c386 https://doi.org/10.1038/s41467-021-25303-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....384b66c84dec970c0da66dd99851c386 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20411723 |
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