Varenicline Effects on Smoking, Cognition, and Psychiatric Symptoms in Schizophrenia: A Double-Blind Randomized Trial
| العنوان: | Varenicline Effects on Smoking, Cognition, and Psychiatric Symptoms in Schizophrenia: A Double-Blind Randomized Trial |
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| المؤلفون: | Lawrence Maayan, Mark Weiser, Sylvia Boules, Tian-Mei Si, Juanjuan Ren, Robert C. Smith, Hua Jin, Mary Youseff, Revital Amiaz, Abel Lajtha, Yanhong Liu, John M. Davis, Chunbo Li, Alessandro Guidotti, Henry Sershen |
| المصدر: | PLoS ONE, Vol 11, Iss 1, p e0143490 (2016) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Placebo-controlled study, lcsh:Medicine, Biology, Placebo, law.invention, 03 medical and health sciences, chemistry.chemical_compound, Cognition, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, Nicotinic Agonists, Cotinine, Varenicline, Psychiatry, lcsh:Science, Smoking Reduction, Psychological Tests, Multidisciplinary, Depression, Smoking, lcsh:R, Nausea, Middle Aged, medicine.disease, Nicotine replacement therapy, Tobacco Use Cessation Devices, 030227 psychiatry, chemistry, Schizophrenia, Smoking cessation, Female, Schizophrenic Psychology, Smoking Cessation, lcsh:Q, Symptom Assessment, 030217 neurology & neurosurgery, Antipsychotic Agents, Research Article |
| الوصف: | UNLABELLED:Schizophrenic patients have a high rate of smoking and cognitive deficits which may be related to a decreased number or responsiveness of nicotinic receptors in their brains. Varenicline is a partial nicotinic agonist which is effective as an antismoking drug in cigarette smokers, although concerns have been raised about potential psychiatric side-effects. We conducted a double-blind placebo controlled study in 87 schizophrenic smokers to evaluate the effects of varenicline (2 mg/day) on measures of smoking, cognition, psychiatric symptoms, and side-effects in schizophrenic patients who were cigarette smokers. Varenicline significantly decreased cotinine levels (P |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3866262a71388b1525d9e463f4cba5aa http://europepmc.org/articles/PMC4701439?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3866262a71388b1525d9e463f4cba5aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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