Specificity and promiscuity of gonadotropin receptors
| العنوان: | Specificity and promiscuity of gonadotropin receptors |
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| المؤلفون: | Sabine Costagliola, Gilbert Vassart, Fernando Mendive, Eneko Urizar |
| المصدر: | Reproduction. 130:275-281 |
| بيانات النشر: | Bioscientifica, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | endocrine system, Embryology, medicine.medical_specialty, G protein, medicine.drug_class, Plasma protein binding, Biology, Binding, Competitive, Chorionic Gonadotropin, Human chorionic gonadotropin, Ovarian Hyperstimulation Syndrome, Receptors, Gonadotropin, Endocrinology, Internal medicine, medicine, Animals, Humans, Receptor, Obstetrics and Gynecology, Cell Biology, Protein Structure, Tertiary, Reproductive Medicine, Ectodomain, Hormone receptor, Receptors, FSH, Female, Gonadotropin, Follicle-stimulating hormone receptor, Dimerization, Gonadotropins, hormones, hormone substitutes, and hormone antagonists, Protein Binding |
| الوصف: | The dichotomy between hormone recognition by the ectodomain and activation of the G protein by the rhodopsin-like serpentine portion is a well established property of glycoprotein hormone receptors. The specificity barrier avoiding promiscuous activation of the FSH receptor by the high concentration of human chorionic gonadotropin (hCG) prevailing during human pregnancy was thus believed to lie in the ectodomain. In the past two years, mutations responsible for rare spontaneous cases of ovarian hyperstimulation syndromes have partially modified this simple view. Five naturally occurring mutations have been identified which cause an increase in the sensitivity of the FSH receptor to hCG. Surprisingly, these mutations are all located in the serpentine portion of the receptor. In addition to their effect on sensitivity to hCG, they increase sensitivity of the FSH receptor to TSH, and are responsible for activating the receptor constitutively. Together, the available information indicates that the ectodomain and the serpentine domain of the FSH receptor each contribute to the specificity barrier preventing its spurious activation by hCG. While the former is responsible for establishment of binding specificity, the latter introduces a novel notion of functional specificity.Recent data demonstrate that LH and FSH receptors can constitute functional homo- and heterodimers. This suggests the possibility that in cells co-expressing the two receptors, such as granulosa cells, the heterodimers might be endowed with functional characteristics different from those of each homodimer. |
| تدمد: | 1741-7899 1470-1626 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3880a065edfdc5e41d4f680c34796861 https://doi.org/10.1530/rep.1.00662 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3880a065edfdc5e41d4f680c34796861 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417899 14701626 |
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