SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease
| العنوان: | SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease |
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| المؤلفون: | Pradoldej Sompol, Shan Ping Yu, Yi Hong, Chi Bun Chan, Peng Jin, Keqiang Ye, Xia Liu, Xuekun Li, Il Sun Kwon, Mingke Song, Hyun Pil Lee, Hyoung Gon Lee |
| المصدر: | The Journal of Neuroscience. 32:17262-17272 |
| بيانات النشر: | Society for Neuroscience, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Neurite, Mice, Transgenic, tau Proteins, Protein Serine-Threonine Kinases, Biology, Article, Presenilin, Microtubule polymerization, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, mental disorders, Neurites, Presenilin-1, medicine, Animals, Humans, Phosphorylation, Maze Learning, Neurons, Neuronal Plasticity, Behavior, Animal, Kinase, General Neuroscience, Dentate gyrus, Brain, Long-term potentiation, medicine.disease, Disease Models, Animal, nervous system, Alzheimer's disease, Neuroscience |
| الوصف: | Serine-arginine protein kinases 2 (SRPK2) is a cell cycle-regulated kinase that phosphorylates serine/arginine domain-containing proteins and mediates pre-mRNA splicing with unclear function in neurons. Here, we show that SRPK2 phosphorylates tau on S214, suppresses tau-dependent microtubule polymerization, and inhibits axonal elongation in neurons. Depletion of SRPK2 in dentate gyrus inhibits tau phosphorylation in APP/PS1 mouse and alleviates the impaired cognitive behaviors. The defective LTP in APP/PS1 mice is also improved after SRPK2 depletion. Moreover, active SRPK2 is increased in the cortex of APP/PS1 mice and the pathological structures of human Alzheimer's disease (AD) brain. Therefore, our study suggests SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of AD. |
| تدمد: | 1529-2401 0270-6474 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3886baea4814339433572e9e8a691bb8 https://doi.org/10.1523/jneurosci.3300-12.2012 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3886baea4814339433572e9e8a691bb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292401 02706474 |
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