Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin’s lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19)
| العنوان: | Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin’s lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19) |
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| المؤلفون: | K. Bremer, P. Richter, Andreas Schwarzer, Chr. Müller, Rita Pasold, Manfred Schulze, Dietger Niederwieser, Chr. Klinkenstein, Klaus Dachselt, J. Weniger, C. Boewer, H. Arzberger, Mathias Freund, Antje Schulze, Cornelia Winkelmann, C. A. Müller, Veronika Schirmer, B. Ismer, Hans-Joerg Fricke, A. Franke, S. Hahnfeld, Michael Herold |
| المصدر: | Journal of Cancer Research and Clinical Oncology. 132:105-112 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Bendamustine, Cancer Research, medicine.medical_specialty, Vincristine, Cyclophosphamide, Follicular lymphoma, Lymphoma, Mantle-Cell, Gastroenterology, Disease-Free Survival, Lymphoplasmacytic Lymphoma, Prednisone, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Bendamustine Hydrochloride, Humans, Lymphoma, Follicular, Aged, business.industry, Lymphoma, Non-Hodgkin, General Medicine, Middle Aged, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Survival Analysis, Surgery, Non-Hodgkin's lymphoma, Treatment Outcome, Oncology, Nitrogen Mustard Compounds, Female, Mantle cell lymphoma, business, medicine.drug |
| الوصف: | Purpose: The purpose of this study was to compare the efficacy and toxicity of bendamustine, vincristine + prednisone (BOP) with a standard regimen of cyclophosphamide, vincristine + prednisone (COP) in patients with previously untreated advanced indolent non-Hodgkin’s lymphoma (NHL) and mantle cell lymphoma. Methods: A total of 164 patients with follicular lymphoma (grade 1/2), mantle cell lymphoma or lymphoplasmacytic lymphoma (immunocytoma) was randomised to treatment with vincristine 2 mg (day 1) and prednisone 100 mg/m2 (days 1–5) + bendamustine 60 mg/m2 (days 1–5) or + cyclophosphamide 400 mg/m2 (days 1–5) for a total of eight 21-day cycles. Results: The rate of complete remission was 22% with BOP and 20% with COP. The projected 5-year survival rate was 61% with BOP and 46% with COP. The BOP-associated 5-year survival advantage almost reached significance in the subgroup of patients who responded to therapy (74% vs. 56%; P=0.05), and did reach significance in responders who did not receive interferon maintenance therapy (70% vs. 47%; P=0.03). Toxicity was acceptable in both treatment groups, although alopecia and leucopenia were more severe with COP. Conclusions: Bendamustine can efficaciously and safely replace cyclophosphamide, as used in standard COP therapy, for the treatment of patients with indolent NHL and mantle cell lymphoma. Long-term survival data suggest a clinically significant benefit for patients treated with BOP |
| تدمد: | 1432-1335 0171-5216 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3908c97de478ac384f6f92ad6ae8c28e https://doi.org/10.1007/s00432-005-0023-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3908c97de478ac384f6f92ad6ae8c28e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321335 01715216 |
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