التفاصيل البيبلوغرافية
العنوان:
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential
المؤلفون:
Helene Sahri , Julie Christie , Neil John Press , Mark Keenan , Sandra Haberthuer , Morris Tweed , Andrew R. Tuffnell , Mark Mercer , Joseph D. Fullerton , John R. Fozard , Thomas H. Keller , Nicola Elaine Press , Lyndon Nigel Brown , Roger J. Taylor , Clive Mccarthy , Julia Hatto , Robert Cheung , Pamela Tranter
المصدر:
Bioorganic & Medicinal Chemistry Letters . 15:3081-3085
بيانات النشر:
Elsevier BV, 2005.
سنة النشر:
2005
مصطلحات موضوعية:
medicine.drug_class , Clinical Biochemistry , Adenosine A3 Receptor Antagonists , Pharmaceutical Science , Pharmacology , Receptor, Adenosine A2B , Adenosine receptor antagonist , Biochemistry , Structure-Activity Relationship , chemistry.chemical_compound , Aminothiazole , Heterocyclic Compounds , Drug Discovery , medicine , Animals , Rats, Wistar , Receptor , Molecular Biology , ADME , Chemistry , Receptor, Adenosine A3 , Organic Chemistry , Antagonist , Receptor antagonist , Adenosine , Adenosine receptor , Adenosine A2 Receptor Antagonists , Rats , Thiazoles , Molecular Medicine , medicine.drug
الوصف:
The synthesis and SAR of 5-heterocycle-substituted aminothiazole adenosine receptor antagonists is described. Several compounds show high affinity and selectivity for the A2B and A3 receptors. One compound (5f) shows good ADME properties in the rat and as such may be an important new compound in testing the current hypotheses proposing a therapeutic role for a dual A2B/A3 antagonist in allergic diseases.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3947523839cef2983228f572e9013e7c https://doi.org/10.1016/j.bmcl.2005.04.021
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....3947523839cef2983228f572e9013e7c
قاعدة البيانات:
OpenAIRE
