MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma
| العنوان: | MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma |
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| المؤلفون: | Giuseppe Giaccone, Aaron J. Schetter, Elisabeth Brambilla, Iacopo Petrini, Trung C. Pham, Helmut Popper, Curtis C. Harris, Mohammed A. Khan, Martin Filipits, Akiteru Goto, Alan Lee, Ariane Dunant, Jean-Pierre Pignon, Jane J. Sohn, Pierre Hainaut, Jean Mendiboure, Johannes Voortman, Motonobu Saito |
| المساهمون: | Internal medicine, CCA - Innovative therapy |
| المصدر: | Cancer Research, 70(21), 8288-8298. American Association for Cancer Research Inc. Voortman, J, Goto, A, Mendiboure, J, Sohn, J J, Schetter, A J, Saito, M, Dunant, A, Pham, T C, Petrini, I, Lee, A, Khan, M A, Hainaut, P, Pignon, J P, Brambilla, E, Popper, H H, Filipits, M, Harris, C C & Giaccone, G 2010, ' MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non-Small Cell Lung Carcinoma ', Cancer Research, vol. 70, no. 21, pp. 8288-8298 . https://doi.org/10.1158/0008-5472.CAN-10-1348 |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Oncology, Male, Pathology, Cancer Research, Lung Neoplasms, Messenger, Carcinoma, Non-Small-Cell Lung, Medicine, Epidermal growth factor receptor, Non-Small-Cell Lung, Tumor Markers, Adjuvant, In Situ Hybridization, Paraffin Embedding, biology, Reverse Transcriptase Polymerase Chain Reaction, MicroRNA Expression Profile, Middle Aged, Prognosis, Combined Modality Therapy, Survival Rate, Chemotherapy, Adjuvant, Female, Antineoplastic Agents, Cisplatin, Humans, MicroRNAs, Mutation, Neoplasm Invasiveness, RNA, Messenger, Tumor Markers, Biological, Tumor Suppressor Protein p53, medicine.drug, medicine.medical_specialty, Article, Internal medicine, microRNA, Biomarkers, Tumor, Carcinoma, Chemotherapy, Lung cancer, Survival rate, business.industry, Cancer, medicine.disease, Biological, biology.protein, RNA, business |
| الوصف: | This study determined whether expression levels of a panel of biologically relevant microRNAs can be used as prognostic or predictive biomarkers in patients who participated in the International Adjuvant Lung Cancer Trial (IALT), the largest randomized study conducted to date of adjuvant chemotherapy in patients with radically resected non–small cell lung carcinoma (NSCLC). Expression of miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a was determined by quantitative real-time PCR in formalin-fixed paraffin-embedded tumor specimens from 639 IALT patients. The prognostic and predictive values of microRNA expression for survival were studied using a Cox model, which included every factor used in the stratified randomization, clinicopathologic prognostic factors, and other factors statistically related to microRNA expression. Investigation of the expression pattern of microRNAs in situ was performed. We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression. Finally, the association of p16 and miR-29b expression was assessed. Overall, no significant association was found between any of the tested microRNAs and survival, with the exception of miR-21 for which a deleterious prognostic effect of lowered expression was suggested. Otherwise, no single or combinatorial microRNA expression profile predicted response to adjuvant cisplatin-based chemotherapy. Together, our results indicate that the microRNA expression patterns examined were neither predictive nor prognostic in a large patient cohort with radically resected NSCLC, randomized to receive adjuvant cisplatin-based chemotherapy versus follow-up only. Cancer Res; 70(21); 8288–98. ©2010 AACR. |
| اللغة: | English |
| تدمد: | 0008-5472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395a0b43a9d1ddf43ae0c674583b9915 https://europepmc.org/articles/PMC2970724/ |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....395a0b43a9d1ddf43ae0c674583b9915 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00085472 |
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