The Effects of Monosodium Glutamate and Tannic Acid on Adult Rats
| العنوان: | The Effects of Monosodium Glutamate and Tannic Acid on Adult Rats |
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| المؤلفون: | Ahu Soyocak, Umut Kerem Kolac, Varol Sahinturk, Fezan Mutlu, Irfan Degirmenci, Didem Turgut Coşan, Faruk Saydam, Zeynep Ozdemir Koroglu, Hulyam Kurt, Hasan Veysi Gunes, İbrahim Uğur Çaliş |
| المساهمون: | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Saydam, Faruk |
| المصدر: | Iranian Red Crescent Medical Journal |
| بيانات النشر: | DoNotEdit, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Antioxidant, Monosodium glutamate, medicine.medical_treatment, medicine.disease_cause, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Tannic acid, Medicine, Saline, Monosodium Glutamate, Kidney, biology, business.industry, General Medicine, Malondialdehyde, Tannic Acid, Oxidative Stress, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Biochemistry, biology.protein, business, 030217 neurology & neurosurgery, Oxidative stress, Research Article |
| الوصف: | Cosan, Didem Turgut/0000-0002-8488-6405; Sahinturk, Varol/0000-0003-2317-3644; Calis, Ibrahim Ugur/0000-0003-2907-2035 WOS: 000390300000020 PubMed: 28184327 Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. the excessive use of MSG has been shown to increase oxidative stress in different organ systems and causes glucose metabolism disorders, obesity, and coronary diseases. Objectives: in this study, the antioxidant activity of tannic acid was investigated experimentally with respect to its protective effects against overdosed MSG-induced oxidative stress in rats. the study took place in Turkey in August 2013. Methods: Four groups (n = 7) of three-to four-month-old Sprague-Dawley female rats were used in this study. the first group was the control, who were administered saline. the second group received tannic acid (50 mg/kg, 3 days) intraperitoneally (i.p.). the third group received MSG (2 g/kg, 7 days) i.p., and the fourth group received both tannic acid (50 mg/kg, 3 days, pretreatment) and MSG (2 g/kg, 7 days) i.p. the animals were euthanized ten days later. Blood was collected for determining the hematological values and blood glucose levels. Superoxide dismutase (SOD) andmalondialdehyde(MDA) levels were determined in the brain, liver, and kidney homogenates, and in the erythrocyte hemolysate. Histopathological examination of the brain, liver, and kidneys was conducted through hematoxylin-eosin staining. Results: the data showed that the tannic acid treatment statistically decreased the MDA levels in the brain tissues of the group administered MSG and tannic acid (P < 0.001) when compared to the corresponding values of the control group. the SOD activities in the blood hemolysates of the MSGandtannic acid group increased when compared to the corresponding values for the MSGgroup (P < 0.01). Additionally, we found that pretreatment with tannic acid reduced blood glucose levels in comparison to the levels of the MSG group (P = 0.029). the results of our study show that tannic acid pretreatment in adult rats decreased blood glucose levels and oxidative stress. Conclusions: in the literature, it was observed that short-term MSG exposure does not cause significant histological changes in the kidneys, liver, or brain cortex. These findings should be re-evaluated in additional long-term studies. |
| وصف الملف: | application/pdf |
| تدمد: | 2074-1812 2074-1804 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39867a5a1dca0b07d83e9b207fc2c2d6 https://doi.org/10.5812/ircmj.37912 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....39867a5a1dca0b07d83e9b207fc2c2d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20741812 20741804 |
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