Implantation of autologous muscle-derived stem cells in treatment of fecal incontinence: results of an experimental pilot study
| العنوان: | Implantation of autologous muscle-derived stem cells in treatment of fecal incontinence: results of an experimental pilot study |
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| المؤلفون: | Maciej Kurpisz, Agnieszka Malcher, Natalia Rozwadowska, Piotr Wałęga, Michał Romaniszyn, Tomasz Kolanowski |
| المصدر: | Techniques in Coloproctology |
| بيانات النشر: | Springer Milan, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | electromyography, medicine.medical_specialty, External anal sphincter, Stem cells, Myoblasts, fluids and secretions, stem cells, Fecal incontinence, Muscle regeneration, medicine, Myocyte, Prospective cohort study, muscle regeneration, business.industry, Electromyography, myoblasts, Gastroenterology, Anal canal, Anal manometry, musculoskeletal system, Colorectal surgery, Surgery, fecal incontinence, anal manometry, medicine.anatomical_structure, Original Article, medicine.symptom, Stem cell, business, Abdominal surgery |
| الوصف: | Background The aim of this study is to present results of the implantation of autologous myoblasts into the external anal sphincter (EAS) in ten patients with fecal incontinence. Methods After anatomical and functional assessment of the patients’ EAS, a vastus lateralis muscle open biopsy was performed. Stem cells were extracted from the biopsy specimens and cultured in vitro. Cell suspensions were then administered to the EAS. Patients were scheduled for follow-up visits in 6-week intervals. Total follow-up was 12 months. Results All biopsy and cell implantation procedures were performed without complications. Nine of the patients completed a full 12-month follow-up. There was subjective improvement in six patients (66.7 %). In manometric examinations 18 weeks after implantation, squeeze anal pressures and high-pressure zone length increased in all patients, with particularly significant sphincter function recovery in five patients (55.6 %). Electromyographic (EMG) examination showed an increase in signal amplitude in all patients, detecting elevated numbers of propagating action potentials. Twelve months after implantation two patients experienced deterioration of continence, which was also reflected in the deterioration of manometric and EMG parameters. The remaining four patients (44.4 %) still described their continence as better than before implantation and retained satisfactory functional examination parameters. Conclusions Implantation of autologous myoblasts gives good short-term results not only in a subjective assessment, but also in objective functional tests. It seems that this promising technology can improve the quality of life of patients with fecal incontinence, but further study is required to achieve better and more persistent results. |
| اللغة: | English |
| تدمد: | 1128-045X 1123-6337 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398fd9ac0e77692ef3d8510883be0c6a http://europepmc.org/articles/PMC4631713 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....398fd9ac0e77692ef3d8510883be0c6a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1128045X 11236337 |
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