Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study
| العنوان: | Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study |
|---|---|
| المؤلفون: | Mariangela Tripodi, Bartolo Lanuzza, Raffaele Ferri, Debora Aricò, Maria Paola Mogavero, Lourdes M. DelRosso, Filomena I.I. Cosentino, Giuseppe Plazzi, Fabio Pizza, Giuseppe Lanza |
| المساهمون: | Mogavero M.P., Cosentino F.I.I., Lanuzza B., Tripodi M., Lanza G., Arico D., Delrosso L.M., Pizza F., Plazzi G., Ferri R. |
| المصدر: | Brain Sciences; Volume 11; Issue 12; Pages: 1574 Brain Sciences, Vol 11, Iss 1574, p 1574 (2021) Brain Sciences |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Excessive daytime sleepiness, Neurosciences. Biological psychiatry. Neuropsychiatry, Polysomnography, Comorbidity, Article, Internal medicine, Observational study, Medicine, prolactin, hypersomnia, excessive daytime sleepiness, comorbidity, sleep disorders, observational study, Sleep disorder, Hypersomnia, medicine.diagnostic_test, business.industry, General Neuroscience, Sleep disorders, medicine.disease, Sleep in non-human animals, Prolactin, Obstructive sleep apnea, Excessive daytime sleepine, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists, RC321-571 |
| الوصف: | The objectives of this study were: (1) to identify subjects with hyperprolactinemia in a clinical sample of patients; (2) to compare the neurologic, psychiatric, and sleep conditions found in patients subgrouped by excessive daytime sleepiness (EDS) and hyperprolactinemia; and (3) to identify patients with hyperprolactinemia and EDS not supported by the presence of any other neurologic, psychiatric, or sleep disorder, or substance/medication use. A retrospective chart review of inpatients was carried out in order to identify all patients in whom the prolactin (PRL) serum levels were determined. A total of 130 subjects were retrieved: 55 had increased levels of PRL, while the remaining 75 participants had normal PRL levels. EDS was reported by 32 (58.2%) participants with increased PRL and 34 (45.3%) with normal PRL. Obstructive sleep apnea or other sleep or neurologic/psychiatric conditions could explain EDS in all participants with normal PRL. Among subjects with increased PRL, eight had no other neurologic/psychiatric or sleep disorder (or drug) potentially causing EDS; these participants, at polysomnography, had time in bed, sleep period time, and total sleep time longer than those with EDS associated to another condition. These findings can be considered as a preliminary indication of a role of hyperprolactinemia in EDS and represent a basis for future controlled studies able to test this hypothesis in a reliable, objective, and methodologically more appropriate way. |
| وصف الملف: | ELETTRONICO; application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399b4987bedbfd0d0802dd454aa325fe http://hdl.handle.net/20.500.11769/522245 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....399b4987bedbfd0d0802dd454aa325fe |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |