Oesophageal resection for high-grade dysplasia in Barrett's oesophagus
| العنوان: | Oesophageal resection for high-grade dysplasia in Barrett's oesophagus |
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| المؤلفون: | Zaninotto, Giovanni, Parenti, ANNA ROSITA, Ruol, A, Costantini, M, Molena, D., Cagol, M, Buin, Francesca, Merigliano, Stefano, Ancona, Ermanno |
| المصدر: | British Journal of Surgery. 87:1102-1105 |
| بيانات النشر: | Oxford University Press (OUP), 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Adenocarcinoma, Preoperative care, Barrett Esophagus, Humans, Medicine, Survival rate, Aged, medicine.diagnostic_test, business.industry, Esophageal disease, Perioperative, Middle Aged, medicine.disease, Endoscopy, Surgery, Esophagectomy, Treatment Outcome, Dysplasia, Barrett's esophagus, business |
| الوصف: | Background The aims of this study were to evaluate the prevalence of invasive cancer in patients with high-grade dysplasia in Barrett's oesophagus and to verify whether a second endoscopy with multiple biopsies could improve the accuracy of preoperative diagnosis. In addition, the mortality, morbidity and survival rates in patients with high-grade dysplasia having oesophageal resection were recorded. Methods Fifteen patients were observed from 1982 to 1998; the first seven patients were offered primary oesophageal resection after diagnosis. The other eight patients underwent a second endoscopy with a median of 12 biopsies examined. All later underwent oesophageal resection. Results Invasive adenocarcinoma was found in five patients, with a minimal difference between the first and second periods (two of seven versus three of eight). There were no perioperative deaths. Early morbidity was observed in eight patients and late morbidity in four. The actuarial survival rate was 79 per cent at 5 years. The Karnofsky status was unchanged from preoperative values in 13 of 15 patients after a median follow-up of 46 months. Conclusion These patients with high-grade dysplasia had a 33 per cent probability of harbouring invasive oesophageal carcinoma but even a second endoscopy failed to identify patients with invasive tumour. Oesophagectomy was performed with no deaths and remains a rational treatment in patients fit for surgery. |
| تدمد: | 1365-2168 0007-1323 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ba8a517af4c8aa434ce243724809c0 https://doi.org/10.1046/j.1365-2168.2000.01470.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....39ba8a517af4c8aa434ce243724809c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652168 00071323 |
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