Patient characteristics in tardive COVID‐19 pseudoperniosis: a case series of 16 patients
| العنوان: | Patient characteristics in tardive COVID‐19 pseudoperniosis: a case series of 16 patients |
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| المؤلفون: | B. Ganatra, R. Amarnani, Y. Alfallouji, K. Dear, E. Twigg, J. P. Westwood, B. Goulden, V. Morris, T. Hillman, S. Goolamali, Z. Naderi, R. Sidwell, P. Ellery, E. Calonje, G. Kravvas, C. B. Bunker |
| المصدر: | Clinical and Experimental Dermatology |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Time Factors, Adolescent, Concise Report, Coronavirus disease 2019 (COVID-19), Patient characteristics, Connective tissue, Hand Dermatoses, Dermatology, Anorexia, Serology, Cohort Studies, Young Adult, Post-Acute COVID-19 Syndrome, Internal medicine, medicine, Humans, Concise Reports, Aged, Foot Dermatoses, Sickle cell trait, business.industry, COVID-19, Middle Aged, medicine.disease, Chilblains, medicine.anatomical_structure, Acute Disease, Female, CTD, medicine.symptom, business |
| الوصف: | Acute pseudoperniosis (PP) has a recognized association with COVID-19 and tends to occur without cold precipitation in young, healthy patients, often without a clear history of COVID-19. These lesions usually resolve within 2 weeks and without long-term sequelae. In the early months of 2021, patients with delayed and protracted PP began to emerge. We have called this presentation 'tardive COVID-19 PP (TCPP)'.To consolidate and expand knowledge on TCPP, we describe the clinical characteristics, treatments and outcomes of 16 patients with TCPP who were reviewed by our outpatient dermatology service.The initial clinical manifestations were erythema, swelling and PP of the fingers in 56.2%, and of the toes in 31.2%, desquamation in 56.2% and acrocyanosis in 12.5%. Ten patients had eventual involvement of all acral sites. The median duration of symptoms was 191 days. Six patients reported close contact with a confirmed or suspected case of COVID-19, but only two had positive COVID-19 tests. Four patients experienced complete or almost complete resolution of symptoms, while the rest remain under active treatment.Unlike acute PP, TCPP has a protracted and delayed presentation that is typically associated with profound acrocyanosis. Patients with TCPP represent a new phenomenon that is part of the post-COVID-19 syndrome, with risk factors and pathophysiology that are not yet fully understood. Our data indicate that likely predisposing factors for developing TCPP include young age, a preceding history of cold intolerance and an arachnodactyloid phenotype. Anorexia, connective tissue disorders or sickle cell trait may also predispose to TCPP. In addition, low titre antinuclear antibody positivity, the presence of cryoglobulins, or low complement levels may represent further risk factors. Finally, prolonged low temperatures are also likely to be contributing to the symptoms. |
| تدمد: | 1365-2230 0307-6938 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a20c98a6d6f14982737efe3992cbe69 https://doi.org/10.1111/ced.14891 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3a20c98a6d6f14982737efe3992cbe69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652230 03076938 |
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