Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD): data from the PreventCD study
| العنوان: | Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD): data from the PreventCD study |
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| المؤلفون: | Renata Auricchio, María Roca, Carmen Ribes-Koninckx, M. Borrelli, M. L. Mearin, Caroline R. Meijer, Mariantonia Maglio, H Niv-Drori, Raanan Shamir, V Vass, Riccardo Troncone, Ilma Rita Korponay-Szabó |
| المساهمون: | Borrelli, M., Maglio, M., Korponay-Szabó, I. R., Vass, V., Mearin, M. L., Meijer, C., Niv-Drori, H., Ribes-Koninckx, C., Roca, M., Shamir, R., Troncone, R., Auricchio, R. |
| المصدر: | Clinical and Experimental Immunology, 191(3), 311-317 CLINICAL AND EXPERIMENTAL IMMUNOLOGY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Immunoglobulin A, Pathology, Tissue transglutaminase, Biopsy, Antigen-Antibody Complex, Coeliac disease, 0302 clinical medicine, Risk Factors, intestinal deposit, Immunology and Allergy, Medicine, Intestinal Mucosa, Child, PreventCD, medicine.diagnostic_test, biology, Orvostudományok, Prognosis, Europe, Child, Preschool, 030220 oncology & carcinogenesis, Disease Progression, Female, 030211 gastroenterology & hepatology, Antibody, medicine.medical_specialty, Immunology, Klinikai orvostudományok, 03 medical and health sciences, GTP-Binding Proteins, Extracellular, Humans, Protein Glutamine gamma Glutamyltransferase 2, Villous atrophy, Autoantibodies, Transglutaminases, intestinal deposits, business.industry, intestinal anti-TG2 antibodies, Infant, Original Articles, medicine.disease, Staining, Celiac Disease, biology.protein, intestinal anti-TG2 antibodie, Atrophy, business, coeliac disease |
| الوصف: | Summary In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin (Ig)A antibodies (anti-TG2) are produced and deposited in the intestine. PreventCD (www.preventcd.com) is a European multi-centre study, which investigates the influence of infant nutrition and that of genetic, immunological and other environmental factors on the risk of developing CD. The aim of the current study was to evaluate the appearance of intestinal anti-TG2 deposits in very early intestinal biopsies from at-risk infants and their predictive value for villous atrophy. Sixty-five small bowel biopsies, performed in 62 children, were investigated for the presence of intestinal anti-TG2 extracellular IgA deposits by using double immunofluorescence. The biopsies were performed in the presence of elevated serum levels of CD-associated antibodies and/or symptoms suggesting disease. Deposits of anti-TG2 IgA were present in 53 of 53 CD patients and three of three potential CD patients. In potential CD patients, mucosal deposits showed a patchy distribution characterized by some areas completely negative, whereas active CD patients had uniformly present and evident mucosal deposits. Only one of six patients without CD (negative for serum anti-TG2 and with normal mucosa) had intestinal deposits with a patchy distribution and a weak staining. Two of the 53 CD patients received a definitive diagnosis of CD after a second or third biopsy; mucosal deposits of anti-TG2 IgA were evaluated in all samples. Before developing villous atrophy, both patients had anti-TG2 deposits in normal mucosal architecture, antibodies in one patient being absent in serum. We demonstrated that in CD the intestinal deposits of anti-TG2 are a constant presence and appear very early in the natural history of disease. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0009-9104 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3fab9a478fd4dcdbc15318377d5e91 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801494/pdf/CEI-191-311.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3a3fab9a478fd4dcdbc15318377d5e91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00099104 |
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