Potentially beneficial effects of rhamnose on skin ageing: anin vitroandin vivostudy
| العنوان: | Potentially beneficial effects of rhamnose on skin ageing: anin vitroandin vivostudy |
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| المؤلفون: | C. Tran, Sylvie Ricois, Hervé Pageon, A. Azouaoui, Daniel Asselineau, Hélène Zucchi |
| المصدر: | International Journal of Cosmetic Science. 41:213-220 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Collagen Type IV, Aging, Pathology, medicine.medical_specialty, Skin ageing, Rhamnose, Pharmaceutical Science, Dermatology, In Vitro Techniques, 030226 pharmacology & pharmacy, Placebos, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Colloid and Surface Chemistry, Double-Blind Method, In vivo, Clinical investigation, Drug Discovery, medicine, Humans, Beneficial effects, Aged, integumentary system, Chemistry, Papillary dermis, Dermis, Fibroblasts, Middle Aged, In vitro, Skin Aging, Chemistry (miscellaneous), Ageing, Female, Epidermis, Procollagen |
| الوصف: | Recent findings showed that skin ageing preferentially affects human papillary dermal fibroblasts suggesting that the papillary dermis represents a critical zone altered by skin ageing. Based on these findings, we investigated the potential anti-ageing effect of rhamnose.We investigated the potential anti-ageing effect of rhamnose using in vitro reconstructed skin containing fibroblasts obtained either from young or old donors, and in vivo clinical investigation.We detected positive effects of rhamnose in both epidermal and dermal compartments of in vitro reconstructed skin. Moreover, we were able to show that such in vitro findings were also obtained in vivo including an effect on collagen IV and procollagen I production.We provide evidence that rhamnose has a potentially beneficial effect on papillary dermis and dermal-epidermal junction, both of the areas which are affected by skin ageing.Le vieillissement de la peau humaine affecte particulièrement les fibroblastes du derme papillaire suggérant que le derme papillaire représente une zone importante altérée par le vieillissement. A partir de ces résultats, nous avons étudié le potentiel effet anti-âge du rhamnose.Le potentiel effet anti-âge du rhamnose a été étudié in vitro en utilisant un modèle de peau reconstruite contenant des fibroblastes isolés à partir d'un donneur jeune et d'un donneur âgé et dans une étude clinique in vivo. RÉSULTATS: Nous avons observé un effet positif du rhamnose dans le compartiment épidermique et dermique de la peau reconstruite in vitro. En outre, nous avons pu montrer in vivo comme in vitro, un effet sur la production du collagène IV et du procollagène I.Le rhamnose a un effet bénéfique potentiel sur deux zones touchées par le vieillissement cutané, le derme papillaire et la jonction dermo-épidermique. |
| تدمد: | 1468-2494 0142-5463 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51f17a1d597021dbccf3164577826d https://doi.org/10.1111/ics.12523 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3a51f17a1d597021dbccf3164577826d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682494 01425463 |
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