Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study
| العنوان: | Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study |
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| المؤلفون: | Michael E Abram, Deidre E. Wilkins, Fiona Fernandes, Mark T. Esser, Robert Jan Lebbink, Alexey Ruzin, Leyla Kragten-Tabatabaie, Annefleur C Langedijk, Andrey Tovchigrechko, Hong Jin, David E. Tabor, Louis Bont |
| المصدر: | Journal of Clinical Microbiology |
| بيانات النشر: | American Society for Microbiology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Microbiology (medical), Male, Genotype, Epidemiology, viruses, respiratory syncytial virus, Disease, Respiratory Syncytial Virus Infections, Biology, Virus, Neutralization, resistance, South Africa, Japan, Lower respiratory tract infection, Genetic variation, evolution, medicine, Humans, Child, Finland, Phylogeny, Netherlands, Molecular Epidemiology, Molecular epidemiology, Transmission (medicine), Australia, virus diseases, Infant, respiratory system, medicine.disease, Virology, United Kingdom, Spain, Child, Preschool, Respiratory Syncytial Virus, Human, genetic variation, surveillance, Brazil |
| الوصف: | Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia). Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia). RSV B (all BA9 genotype) predominated over RSV A (all ON1 genotype) globally (69.0% versus 31.0%) and in all countries except South Africa. Geographic clustering patterns highlighted wide transmission and continued evolution with viral spread. Most RSV strains were from infants of 24 h (70.5%), with no differences in subtype distribution. Compared to 2013 reference sequences, variations at F protein antigenic sites were observed for both RSV A and B strains, with high-frequency polymorphisms at antigenic site Ø (I206M/Q209R) and site V (L172Q/S173L/K191R) in RSV B strains. The INFORM-RSV 2017–2018 pilot season establishes an important molecular baseline of RSV strain distribution and sequence variability with which to track the emergence of new strains and provide an early warning system of neutralization escape variants that may impact transmission or the effectiveness of vaccines and MAbs under development. |
| اللغة: | English |
| تدمد: | 1098-660X 0095-1137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9311f01fe805c4da4969442d77bdb4 http://europepmc.org/articles/PMC7771447 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3a9311f01fe805c4da4969442d77bdb4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1098660X 00951137 |
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