Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects
| العنوان: | Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects |
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| المؤلفون: | R Landthaler, Ingeborg Walter-Sack, J. X. de Vries, N. Zöllner, A. Ittensohn, W. Löffler, Andreas Voss |
| المصدر: | The Clinical Investigator. 72:1071-1075 |
| بيانات النشر: | Springer Science and Business Media LLC, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Allopurinol, medicine.medical_treatment, Administration, Oral, Oxypurinol, Pharmacology, chemistry.chemical_compound, Hydrochlorothiazide, Reference Values, Oral administration, Internal medicine, Drug Discovery, medicine, Humans, Drug Interactions, Genetics (clinical), Thiazide, Oxipurinol, General Medicine, Drug interaction, Uric Acid, Endocrinology, chemistry, Molecular Medicine, Uric acid, Diuretic, medicine.drug |
| الوصف: | The interaction of allopurinol (300 mg/day) and hydrochlorothiazide (50 mg/day) was studied in seven healthy male volunteers during prolonged coadministration of the two drugs using defined dietary conditions. A formula diet was administered with the allopurinol throughout the 24-day study, while hydrochlorothiazide was added during days 11-21. After the addition of hydrochlorothiazide both plasma uric acid and plasma oxipurinol rose for 6 days--24% and 30%, respectively, compared to steady-state levels during allopurinol alone (P < 0.01 each). In neither substance were variations in renal excretion significant. By the end of combined treatment (day 21), the changes induced by hydrochlorothiazide had already been reversed to a considerable extent. It is concluded that both in normal individuals and in patients with normal renal clearance of uric acid the effect of hydrochlorothiazide on the plasma concentration and renal excretion of oxipurinol is small. When taking both drugs, there is no increased risk during long-term treatment, and a risk is even questionable during the first days. |
| تدمد: | 1432-1440 0941-0198 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaa508f2e050132107c9e29a9a8fd9f https://doi.org/10.1007/bf00577758 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3aaa508f2e050132107c9e29a9a8fd9f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321440 09410198 |
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