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Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

التفاصيل البيبلوغرافية
العنوان: Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation
المؤلفون: Susan L. Neuhausen, Jacek Gronwald, Sofia D. Merajver, Barbara Pasini, Josephine Wagner Costalas, Andrea Eisen, Cezary Cybulski, Christine Rappaport, Noah D. Kauff, Aletta Poll, Carrie Snyder, Carey A. Cullinane, Howard M. Saal, Judy Garber, Joanne L. Blum, Albert E. Chudley, Gillian Mitchell, David M. Euhus, Gareth J.O. Evans, Stephanie A. Cohen, Barbara L. Weber, Siranoush Manoukian, Olufunmilayo I. Olopade, Mary B. Daly, Gad Rennert, Anna Jakubowska, Ophira Ginsburg, Tomasz Huzarski, Seema Panchal, Leigha Senter, John Lunn, Tuya Pal, Ellen Warner, Karen Glass, Susan Armel, Talia Donenberg, Robert E. Reilly, Jeffrey N. Weitzel, Taya Fallen, William D. Foulkes, Sonia Nanda, Pål Møller, Barry P. Rosen, Henry T. Lynch, Christian F. Singer, Eitan Friedman, Peter Ainsworth, Kenneth Offit, Dawna Gilchrist, Daniel Rayson, Charis Eng, Janice Little, Christine Elser, Louise Bordeleau, Wendy McKinnon, Susan T. Vadaparampil, Dana Zakalik, Dominique Stoppa-Lyonnet, Nadine Tung, Lovise Maehle, Ava Kwong, Jeanna McCuaig, Steven A. Narod, Marie E. Wood, Joanne Kotsopoulos, Kevin Sweet, Susan Hatters Friedman, Edmond G. Lemire, André Robidoux, Charmaine Kim-Sing, Fergus J. Couch, Tomasz Byrski, Claudine Isaacs, Beth Y. Karlan, Ping Sun, Rochelle Demsky, Jan Lubinski, Wendy S. Meschino, Raluca N. Kurz, Kelly A. Metcalfe
المصدر: Fertility and sterility. 105(3)
سنة النشر: 2015
مصطلحات موضوعية: endocrine system diseases, medicine.medical_treatment, DNA Mutational Analysis, 0302 clinical medicine, Pregnancy, Risk Factors, Surveys and Questionnaires, Odds Ratio, Medicine, Insemination, Artificial, media_common, Ovarian Neoplasms, 030219 obstetrics & reproductive medicine, Obstetrics, BRCA1 Protein, Obstetrics and Gynecology, Middle Aged, female genital diseases and pregnancy complications, Treatment Outcome, 030220 oncology & carcinogenesis, Female, Risk assessment, Infertility, Adult, medicine.medical_specialty, Reproductive Techniques, Assisted, media_common.quotation_subject, Fertility, Fertilization in Vitro, Risk Assessment, 03 medical and health sciences, Young Adult, Humans, Genetic Predisposition to Disease, Aged, Gynecology, BRCA2 Protein, In vitro fertilisation, Chi-Square Distribution, business.industry, BRCA mutation, Case-control study, Odds ratio, Fertility Agents, Female, medicine.disease, Logistic Models, Reproductive Medicine, Case-Control Studies, Multivariate Analysis, Mutation, business, Ovarian cancer
الوصف: Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18–2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.
تدمد: 1556-5653
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abcd6ba4ab255eb25c183d58fa0c098
https://pubmed.ncbi.nlm.nih.gov/26730498
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....3abcd6ba4ab255eb25c183d58fa0c098
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15565653