Prognostic value of polarized macrophages in patients with hepatocellular carcinoma after curative resection
| العنوان: | Prognostic value of polarized macrophages in patients with hepatocellular carcinoma after curative resection |
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| المؤلفون: | Jin-Liang Ma, Qing-Hua Shu, Dong Liu, Wei-Dong Jia, Ge-Liang Xu, Hua-Xing Ma, Yong-Sheng Ge, Jing-Jing Pan, Xiao-Qiang Gao |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | John Wiley and Sons Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, medicine.medical_specialty, Pathology, Carcinoma, Hepatocellular, CD11c, Kaplan-Meier Estimate, Disease-Free Survival, Metastasis, 03 medical and health sciences, Immune system, Antigens, CD, Internal medicine, medicine, Humans, In patient, Neoplasm Staging, polarization, CD68, business.industry, Proportional hazards model, Macrophages, Liver Neoplasms, Cell Polarity, Cell Biology, Original Articles, hepatocellular carcinoma, Middle Aged, medicine.disease, Prognosis, Immunohistochemistry, 030104 developmental biology, CD206, tumour‐associated macrophages, Hepatocellular carcinoma, Molecular Medicine, Original Article, Female, business |
| الوصف: | As the most predominant tumour‐infiltrating immune cells, tumour‐associated macrophages (TAMs) are significant for fostering tumour growth, progression and metastasis. CD68‐positive TAMs display dissimilarly polarized programmes comprising CD11c‐positive pro‐inflammatory macrophages (M1) and CD206‐positive immunosuppressive macrophages (M2). The aim of this study is to determine the prognostic significance of diametrically polarized TAMs in hepatocellular carcinoma (HCC) and their application to risk stratification of patients according to their specific prognostic values. This study included 80 consecutive patients with HCC, and we evaluated diametrically polarized functional status of macrophages by immunohistochemical staining of CD68, CD11c and CD206. Prognostic values and clinicopathologic features were assessed in these patients. High versus low CD11c‐positive TAM density (P = 0.005) and low versus high CD206‐positive TAM density (P = 0.002) were associated with better overall survival, whereas CD68‐positive TAM density had no prognostic significance (low versus high, P = 0.065). Furthermore, the presence of these positive staining macrophages did not show any prognostic significance for recurrence‐free survival (all P > 0.05). Multivariate Cox regression analysis identified CD11c‐positive and CD206‐positive TAMs as an independent prognostic factor (P < 0.001, P = 0.031, respectively). Intratumoural infiltration of diametrically polarized TAMs, a novel identified independent prognostic factor for survival in patients with HCC, could be combined with the TNM stage and the Barcelona Clinic Liver Cancer stage to improve a risk stratification system. |
| اللغة: | English |
| تدمد: | 1582-4934 1582-1838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad05bb0f6c05be65e8e33767f920b5d http://europepmc.org/articles/PMC4882981 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3ad05bb0f6c05be65e8e33767f920b5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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