Can intermittent, time‐restricted circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study
| العنوان: | Can intermittent, |
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| المؤلفون: | Khalaf Kridin, Hamdi Chtourou, Nicola Luigi Bragazzi, Achraf Ammar, Hristina Kocic, Rosalynn R.Z. Conic, Khaled Trabelsi, Giovanni Damiani, Alessia Pacifico, Piergiorgio Malagoli, Sergio Garbarino, Paolo D. Pigatto |
| المصدر: | Dermatologic Therapy. 34 |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Biological clock, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Internal medicine, Intermittent fasting, Humans, Medicine, Prospective Studies, Circadian rhythm, Dermatological disorders, Prospective cohort study, Skin, business.industry, Weight change, Fasting, General Medicine, Middle Aged, Circadian Rhythm, 030220 oncology & carcinogenesis, Observational study, medicine.symptom, business, human activities |
| الوصف: | The impact of intermittent circadian fasting (ICF) on skin disorders is far to be plenty deciphered. However, the circadian rhythm seems to exert a modulation on dermatoses severity, drug-response, and drug-related side effects. We aimed to evaluate ICF effect in the daily management of dermatological diseases. In this multicenter, prospective observational study we enrolled patients willing to undergo the 2018 ICF (from May 16 to June 14). Dermatoses severity were evaluated at the beginning of ICF (T0) and at the end of ICF (T1) by two independent board-certified dermatologists. Seventy-two patients suffering from different dermatoses volunteered to take part into the study. They displayed a mean age of 40.38 ± 12.46 years (median 41.0 years), 25 subjects were males (34.7% of the entire sample). The median weight change was 0 kg. The overall ICF effect size was -0.58 ([95% CI -0.83 to -0.33], P < .0001, medium effect size). Since in the present investigation no weight loss occurred, we could speculate that the impact of fasting in terms of improvements in the clinical symptoms could be rather due to the perturbation of the human biological clock. Despite our data remain preliminary, a chronobiological approach should be incorporated in the dermatological armamentarium. |
| تدمد: | 1529-8019 1396-0296 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad8175793961af4f115ef5d7ab9e6d5 https://doi.org/10.1111/dth.14912 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3ad8175793961af4f115ef5d7ab9e6d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15298019 13960296 |
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