Distribution of Alkaline Phosphatase, Osteopontin, RANK Ligand and Osteoprotegerin in Calcified Human Carotid Atheroma
| العنوان: | Distribution of Alkaline Phosphatase, Osteopontin, RANK Ligand and Osteoprotegerin in Calcified Human Carotid Atheroma |
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| المؤلفون: | Gerald M. Lawrie, Iou Yih Chen, Catherine L. Higgins, Muthiah Vaduganathan, Salim Isbilir, Pamela Basto, Michael J. Reardon, Leif E. Peterson, Joel D. Morrisett, Periyanan Vaduganathan |
| المصدر: | The Protein Journal. 34:315-328 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, musculoskeletal diseases, medicine.medical_specialty, Bioengineering, Biochemistry, Analytical Chemistry, Bone remodeling, Osteoprotegerin, Calcinosis, Internal medicine, Humans, Medicine, Osteopontin, Aged, Aged, 80 and over, Endarterectomy, Carotid, Receptor Activator of Nuclear Factor-kappa B, biology, business.industry, RANK Ligand, Organic Chemistry, Middle Aged, Alkaline Phosphatase, medicine.disease, Plaque, Atherosclerotic, Arterial calcification, Carotid Arteries, Endocrinology, RANKL, biology.protein, Alkaline phosphatase, Female, business, Biomarkers, Calcification |
| الوصف: | Ectopic vascular calcification is a significant component of atherosclerotic disease. Osteopontin (OPN), Osteoprotegerin (OPG), Receptor Activator of NFκB Ligand (RANKL), and alkaline phosphatase (ALP) are each thought to play central roles in the calcification or demineralization of atherosclerotic lesions. Abnormalities in the balance of these proteins may lead to perturbations in bone remodeling and arterial calcification. The purpose of this study was to measure the distribution of these proteins in human carotid lesions and to elucidate possible mechanism(s) whereby they control the deposition or depletion of arterial calcification. Thirty-three patients who had undergone carotid endarterectomy (CEA) within the previous 18 months and 11 control patients were enrolled. CEA specimens were analyzed by EBCT for calcification content in terms of Agatston (AGAT) and Volume scores. CEA specimens were then cut into 5 mm segments which were homogenized and extracted. Extracts were analyzed for tissue levels of calcium, phosphorus, ALP, OPN, RANKL, and OPG. Fasting blood samples were analyzed for the same components. In CEA tissue segments, the calcification levels (CHA AGAT) were inversely associated with the levels of OPG (r = -0.432/-0.579, p |
| تدمد: | 1875-8355 1572-3887 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af3e2bf6449fc2ab88065e338358732 https://doi.org/10.1007/s10930-015-9620-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3af3e2bf6449fc2ab88065e338358732 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18758355 15723887 |
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