Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders
| العنوان: | Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders |
|---|---|
| المؤلفون: | Md. Torequl Islam |
| المصدر: | Neurological Research. 39:73-82 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Mitochondrial Diseases, Ataxia, Antioxidant, medicine.medical_treatment, Disease, Mitochondrion, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Amyotrophic lateral sclerosis, Fatal familial insomnia, Neurodegenerative Diseases, General Medicine, medicine.disease, nervous system diseases, Cell biology, Oxidative Stress, 030104 developmental biology, Neurology, Biochemistry, Kuru, Neurology (clinical), medicine.symptom, 030217 neurology & neurosurgery, Oxidative stress |
| الوصف: | Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA. Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA. Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzheimer diseases, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Multiple sclerosis, and Parkinson's diseases. In addition, oxidative stress causing protein misfold may turn to other NDDs include Creutzfeldt-Jakob disease, Bovine Spongiform Encephalopathy, Kuru, Gerstmann-Straussler-Scheinker syndrome, and Fatal Familial Insomnia. An overview of the oxidative stress and mitochondrial dysfunction-linked NDDs has been summarized in this review. |
| تدمد: | 1743-1328 0161-6412 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b09e4bb6f92a6b7280cf283f02317f8 https://doi.org/10.1080/01616412.2016.1251711 |
| رقم الأكسشن: | edsair.doi.dedup.....3b09e4bb6f92a6b7280cf283f02317f8 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17431328 01616412 |
|---|