TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda
| العنوان: | TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda |
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| المؤلفون: | Rebecca N Nsubuga, Eugene Kinyanda, Martin Kidd, Allan Kalungi, Moses Joloba, Wilber Ssembajjwe, Soraya Seedat, Jacqueline S. Womersley, Pontiano Kaleebu, Jonathan Levin, Sian M. J. Hemmings |
| المصدر: | BMC Medical Genomics BMC Medical Genomics, Vol 14, Iss 1, Pp 1-10 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, lcsh:Internal medicine, medicine.medical_specialty, lcsh:QH426-470, Adolescent, Genotype, Context (language use), Single-nucleotide polymorphism, 03 medical and health sciences, 0302 clinical medicine, TERC rs16847897, Internal medicine, Genetic variation, Genetics, medicine, Humans, Internalizing mental disorders, Uganda, lcsh:RC31-1245, Child, Telomerase, HIV+ children and adolescents, Genetics (clinical), Depression (differential diagnoses), Telomere length attrition, business.industry, TERT rs2736100, Middle Aged, Telomere, Human genetics, lcsh:Genetics, 030104 developmental biology, Anxiety, RNA, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article |
| الوصف: | Background Internalizing mental disorders (IMDs) (depression, anxiety and post-traumatic stress disorder) have been associated with accelerated telomere length (TL) attrition; however, this association has not been investigated in the context of genetic variation that has been found to influence TL. We have previously reported an association between IMDs and accelerated TL attrition among Ugandan HIV+ children and adolescents. This study investigated the moderating effects of selected single nucleotide polymorphisms in the telomerase reverse transcriptase gene (TERT) (rs2736100, rs7726159, rs10069690 and rs2853669) and the telomerase RNA component gene (TERC) (rs12696304, rs16847897 and rs10936599) on the association between IMDs and TL, among Ugandan HIV+ children (aged 5–11 years) and adolescents (aged 12–17 years). Results We found no significant interaction between IMDs as a group and any of the selected SNPs on TL at baseline. We observed significant interactions of IMDs with TERT rs2736100 (p = 0.007) and TERC rs16847897 (p = 0.012), respectively, on TL at 12 months. Conclusions TERT rs2736100 and TERC rs16847897 moderate the association between IMDs and TL among Ugandan HIV+ children and adolescents at 12 months. Understanding the nature of this association may shed light on the pathophysiological mechanisms underlying advanced cellular aging in IMDs. |
| وصف الملف: | application/pdf |
| تدمد: | 1755-8794 1006-9690 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b73c5b689f7d8a9c81a6c5b1e7a8de9 https://pubmed.ncbi.nlm.nih.gov/33407441 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3b73c5b689f7d8a9c81a6c5b1e7a8de9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17558794 10069690 |
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