Status of vitamin D, antioxidant enzymes, and antioxidant substances in neonates with neonatal hypoxic-ischemic encephalopathy
| العنوان: | Status of vitamin D, antioxidant enzymes, and antioxidant substances in neonates with neonatal hypoxic-ischemic encephalopathy |
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| المؤلفون: | Yakup Aslan, Bilgül Kural, Selim Dereci, Mehmet Mutlu, Şebnem Kader, Cavit Kart, Serap Ozer Yaman, Mehmet Sarıaydın |
| المصدر: | The Journal of Maternal-Fetal & Neonatal Medicine. :1-5 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, Encephalopathy, Hypoxic Ischemic Encephalopathy, Superoxide dismutase, chemistry.chemical_compound, Malondialdehyde, Internal medicine, medicine, Vitamin D and neurology, Humans, Prospective Studies, Cholecalciferol, chemistry.chemical_classification, Glutathione Peroxidase, biology, Superoxide Dismutase, business.industry, Glutathione peroxidase, Infant, Newborn, Obstetrics and Gynecology, medicine.disease, Surgery, Enzyme, Endocrinology, Advanced Oxidation Protein Products, chemistry, Case-Control Studies, Hypoxia-Ischemia, Brain, Pediatrics, Perinatology and Child Health, biology.protein, Female, business |
| الوصف: | To investigate the concentration of vitamin D (VD), glutathione peroxidase (GP), superoxide dismutase (SOD), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) in neonates with hypoxic-ischemic encephalopathy (HIE).This study was performed prospectively in term neonates treated for HIE. Samples were collected from the neonates in study and control groups at 6-14 h and on day 5 of their lives for 25-OH vitamin D3, antioxidant enzymes including GP and SOD and oxidants substances including MDA and AOPP.This study was performed with 31 term neonates with HIE and 30 healthy term neonates. Maternal VD level was statistically lower in the study group (9.8 ± 6.8 ng/mL) than the control (16.4 ± 8.7 ng/mL) (p = 0.002). SOD and MDA levels were significantly high, and VD level was significantly low in the study group on the first day of life (p = 0.001 and p = 0.028, respectively). SOD and GP levels were significantly high in the study group on day 5 (p0.05). VD was significantly low in the study group on day 5 and the proportion of subjects with VD below 5 ng/ml was significantly lower in the control group (p= 0.05).VD has neuroprotective and antioxidant properties. We detected VD levels were low in infants with HIE and their mothers. This finding may be useful for decreasing of brain damage. |
| تدمد: | 1476-4954 1476-7058 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b77b45584ef22b6a770f1cbeb00c250 https://doi.org/10.3109/14767058.2015.1081889 |
| رقم الأكسشن: | edsair.doi.dedup.....3b77b45584ef22b6a770f1cbeb00c250 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14764954 14767058 |
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