Survival Outcomes of Screening with Breast MRI in Women at Elevated Risk of Breast Cancer
| العنوان: | Survival Outcomes of Screening with Breast MRI in Women at Elevated Risk of Breast Cancer |
|---|---|
| المؤلفون: | Blanca Bernard-Davila, Elizabeth J. Sutton, Christopher Comstock, Janice S. Sung, Min Sun Bae, Elizabeth A. Morris |
| المصدر: | J Breast Imaging |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Obstetrics, Significant difference, Cancer, Retrospective cohort study, Magnetic resonance imaging, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Increased risk, Breast cancer, 030220 oncology & carcinogenesis, Medicine, Breast MRI, Mammography, Radiology, Nuclear Medicine and imaging, business, Original Research |
| الوصف: | Objective To determine survival outcomes in women with breast cancer detected at combined screening with breast MRI and mammography versus screening mammography alone. Methods This is an institutional review board-approved retrospective study, and the need for informed consent was waived. A total of 3002 women with an increased risk of breast cancer were screened between 2001 and 2004. Of the 3002 women, 1534 (51.1%) had 2780 combined screenings (MRI and mammography) and 1468 (48.9%) had 4811 mammography-only screenings. The Χ2 test and the Kaplan-Meier method were used to compare cancer detection rates and survival rates. Results The overall cancer detection rate was significantly higher in the MRI plus mammography group compared with the mammography-only group (1.4% [40 of 2780] vs 0.5% [23 of 4811]; P < 0.001). No interval cancers occurred in the MRI plus mammography group, whereas 9 interval cancers were found in the mammography-only group. During a median follow-up of 10.9 years (range: 0.7 to 15.2), a total of 11 recurrences and 5 deaths occurred. Of the 11 recurrences, 6 were in the MRI plus mammography group and 5 were in the mammography-only group. All five deaths occurred in the mammography-only group. Disease-free survival showed no statistically significant difference between the two groups (P = 0.32). However, overall survival was significantly improved in the MRI plus mammography group (P = 0.002). Conclusion Combined screening with MRI and mammography in women at elevated risk of breast cancer improves cancer detection and overall survival. |
| تدمد: | 2631-6129 2631-6110 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7c65033c511028c91c316c56d2d609 https://doi.org/10.1093/jbi/wbz083 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3b7c65033c511028c91c316c56d2d609 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26316129 26316110 |
|---|