Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
| العنوان: | Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis |
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| المؤلفون: | Ling Li, Shizhen Zhang, Jinlan Shan, Zhen Wang, Rui Lei, Siqi Guan, Xiuyan Yu, Daozhe Lin, Xiaochen Wang |
| المصدر: | Medicine |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Colorectal cancer, colorectal cancer, 03 medical and health sciences, 0302 clinical medicine, Text mining, Medicine, Humans, Prospective cohort study, beta Catenin, Neoplasm Staging, business.industry, General Medicine, β-catenin, Subcellular localization, medicine.disease, meta-analysis, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Cytoplasm, 030220 oncology & carcinogenesis, Meta-analysis, Catenin, Cancer research, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Disease Progression, prognosis, business, Colorectal Neoplasms, Nucleus, Systematic Review and Meta-Analysis, Research Article |
| الوصف: | Supplemental Digital Content is available in the text Background: The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined. Methods: Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients’ clinicopathological features or prognosis was analyzed. Results: Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08–2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15–1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85–1.18]) did not show significant association with 5-year OS. Conclusion: This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results. |
| تدمد: | 1536-5964 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7d5329de83c83881512527625b3f02 https://pubmed.ncbi.nlm.nih.gov/31305647 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3b7d5329de83c83881512527625b3f02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 |
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