Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration
| العنوان: | Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration |
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| المؤلفون: | Wei Luo, Jie Gao, Anqi Jiao, Shihao Zhang, Xiajie Lin, Peihao Cai, Yamin Li, Yan Wu, Hong Jiachan, Changsheng Liu, Zeren Zhang, Yulin Li, Xiaofeng Qiu, Xiaohui Zhang, Yuhong Zhang |
| المصدر: | Bioactive Materials, Vol 6, Iss 10, Pp 3461-3472 (2021) Bioactive Materials |
| بيانات النشر: | KeAi Communications Co., Ltd., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | QH301-705.5, 0206 medical engineering, Biomedical Engineering, Emulsion polymerization, 02 engineering and technology, Polylactide, Article, Biomaterials, In vivo, Biology (General), Cell adhesion, Materials of engineering and construction. Mechanics of materials, chemistry.chemical_classification, Nanofibrous membrane, Reactive oxygen species, integumentary system, Chemistry, Regeneration (biology), 021001 nanoscience & nanotechnology, 020601 biomedical engineering, In vitro, Skin regeneration, Membrane, Biophysics, TA401-492, Redox sensitivity, ROS-Balance capacity, 0210 nano-technology, Wound healing, Biotechnology |
| الوصف: | Facing the high incidence of skin diseases, it is urgent to develop functional materials with high bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in the wound healing process mainly via adjustment of immune response and neovasculation. In this study, we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy. Firstly, redox-sensitive poly(N-isopropylacrylamide-acrylic acid) (PNA) nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker. The resulting nanogels were then incorporated into the nanofibrous membrane of poly(l-lactic acid) (PLLA) via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity. In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane. In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process, where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy. Graphical abstract ROS-balance nanofibrous bioabsorbable membrane enables an accelerated wound healing process via promoting cell proliferation and neovascularization.Image 1 Highlights • Redox-sensitive nanogels are synthesized using a disulfide molecule as crosslinker. • Nanofibrous membrane is fabricated via nanogel hybridization by an airbrushing approach. • Nanogel-modified membrane presents adjustable hydrophilicity and redox status, promoting cell adhesion and proliferation. • The ROS-balance membrane can create good microenvironments to promote wound healing efficacy. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba8afa4ab8b6371af502c781a561ad7 http://www.sciencedirect.com/science/article/pii/S2452199X21001109 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3ba8afa4ab8b6371af502c781a561ad7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |