Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil
| العنوان: | Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil |
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| المؤلفون: | Marília Salgado-Caxito, Julio A. Benavides, Lina M Rivas, Jose M. Munita, Fernando José Paganini Listoni, Andrea I. Moreno-Switt, Antonio Carlos Paes, Patricia García |
| المساهمون: | Universidade Estadual Paulista (Unesp), Millennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R), Universidad Andres Bello, Universidad del Desarrollo, Pontificia Universidad Católica de Chile |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Veterinary medicine, Cefotaxime, 040301 veterinary sciences, medicine.drug_class, 030231 tropical medicine, Antibiotics, Cephalosporin, Antimicrobial resistance, medicine.disease_cause, Cefpodoxime, beta-Lactamases, 0403 veterinary science, 03 medical and health sciences, chemistry.chemical_compound, Feces, Hospitals, Animal, 0302 clinical medicine, Dogs, Food Animals, Risk Factors, Drug Resistance, Bacterial, medicine, Escherichia coli, Animals, Cefoxitin, Dog Diseases, Hospitals, Teaching, Escherichia coli Infections, business.industry, Deworming, E. coli, 04 agricultural and veterinary sciences, Companion animals, Extended-spectrum beta-lactamase, Anti-Bacterial Agents, Cephalosporins, Latin America, chemistry, embryonic structures, Carrier State, Ceftriaxone, Animal Science and Zoology, business, MacConkey agar, Brazil, medicine.drug |
| الوصف: | Made available in DSpace on 2021-06-25T10:55:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R E. coli) in dogs has been reported worldwide and can reduce the effectiveness of treatments against bacterial infections. However, the drivers that influence faecal carriage of ESC-R E. coli in dogs are poorly understood. The aims of this study were to estimate the prevalence of ESC-R E. coli among dogs prior to their admission to a veterinary teaching hospital and to identify risk factors associated with the faecal carriage of ESC-R E. coli. Rectal swabs (n = 130) were collected from dogs and screened for ESC-R E. coli using MacConkey agar supplemented with cefotaxime (2 μg/mL). E. coli species was confirmed by MALDI-TOF and screening of extended-spectrum beta-lactamase (ESBL) genes was conducted by multiplex PCR. Questionnaires were completed by each dog's owner to test several human and dog characteristics associated with ESC-R E. coli. The prevalence of faecal carriage of ESC-R E. coli was 9.2 % and 67 % of ESC-R E. coli isolates harboured ESBL genes including CTX-M alone or in combination with TEM. All ESC-R E. coli isolates were resistant to ceftriaxone, cefpodoxime, and cefotaxime and were susceptible to cefoxitin and carbapenems. The likelihood of carrying ESC-R E. coli was 15 times higher (OR = 14.41 [95 % CI: 1.80−38.02], p < 0.01) if the dog was treated with antibiotics 3–12 months prior to sampling and 8 times higher (OR = 7.96 [95 % CI: 2.96−92.07], p < 0.01) if the dog had direct contact with livestock, but 15 times lower (OR = 0.07 [95 % CI: 0.01−0.32], p < 0.01) if the dog was dewormed during the previous year. Our findings confirm the faecal carriage of ESC-R E. coli in subclinical dogs and call for further investigation regarding the impact of deworming on antibiotic-resistant bacteria in companion animals. Department of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Sao Paulo State University (UNESP) Millennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R) Departamento de Ecología y Biodiversidad Facultad de Ciencias de la Vida Universidad Andres Bello Centro de Investigación para la Sustentabilidad Universidad Andres Bello, Facultad de Ciencias de la Vida Genomics and Resistant Microbes Group Facultad de Medicina Clínica Alemana Universidad del Desarrollo Escuela de Medicina Facultad de Medicina Pontificia Universidad Católica de Chile Escuela de Medicina Veterinaria Pontificia Universidad Católica de Chile Department of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Sao Paulo State University (UNESP) |
| تدمد: | 1873-1716 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb97e71644f6f853d459c7b8eb1d133 https://pubmed.ncbi.nlm.nih.gov/33725561 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3bb97e71644f6f853d459c7b8eb1d133 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18731716 |
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