Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomised controlled trials
| العنوان: | Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomised controlled trials |
|---|---|
| المؤلفون: | S. Meyboom, M.B. Katan, R. Hovenier, R. Urgert, M.P.M.E. Weusten-van der Wouw, A. C. Beynen |
| المساهمون: | Faculty of Science |
| المصدر: | European Journal of Clinical Nutrition, 51, 431-436 Urgert, R, Weusten-van der Wouw, M P M E, Hovenier, R, Meyboom, S, Beynen, A C & Katan, M B 1997, ' Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomized controlled trials ', European Journal of Clinical Nutrition, vol. 5, no. 7, pp. 431-436 . European Journal of Clinical Nutrition 51 (1997) European Journal of Clinical Nutrition, 5(7), 431-436. Nature Publishing Group |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Male, Cafestol, Kahweol, Medicine (miscellaneous), Coffee, Experiment, chemistry.chemical_compound, Animal science, Blood plasma, Humans, Medicine, Potency, Coffee bean, Adverse effect, VLAG, Human Nutrition & Health, Nutrition and Dietetics, biology, business.industry, Humane Voeding & Gezondheid, Lipoprotein(a), Lipid Metabolism, Lipid metabolism, Liver, chemistry, Biochemistry, biology.protein, Female, Diterpenes, business, Human, medicine.drug, Lipoprotein |
| الوصف: | Objective: Unfiltered coffee raises serum LDL cholesterol in humans, owing to the presence of the diterpenes cafestol and kahweol. Norwegians with a chronic high intake of unfiltered coffee also had elevated serum levels of lipoprotein(a), an LDL-like particle which is insensitive toward dietary interventions. We now experimentally studied the influence of coffee diterpenes on lipoprotein(a) levels. Design: Four randomised controlled trials. Subjects: Healthy, normolipidemic volunteers. Interventions: Coffee, coffee oil, and pure diterpenes for 4‐24 weeks. Main outcome measures: The circulating level of lipoprotein(a). Results: In 22 subjects drinking five to six strong cups of cafetiere coffee per day, the median fall in lipoprotein(a) was 1.5 mg/dL after two months (Pa 0.03), and 0.5 mg/dL after half a year (P> 0.05), relative to 24 filter coffee drinkers. Coffee oil doses equivalent to 10‐20 cups of unfiltered coffee reduced lipoprotein(a) levels by up to 5.5 mg/dL (P< 0.05) in two separate trials (na 12‐16 per group). A purified mixture of cafestol and kahweol, as well as cafestol alone, were also effective in reducing Lp(a) levels (na 10). Averaged over the four trials, each 10 mg/d of cafestol (plus kahweol)—the amount present in two to three cups of cafetiere coffee—decreased Lp(a) levels by 0.5 mg/dL or 4% from baseline values after four weeks (na 63). Conclusions: Coffee diterpenes are among the few dietary exceptions shown to influence serum lipoprotein(a) levels. However, the Lp(a)-reducing potency of coffee diterpenes may subside in the long run, and their adverse side effects preclude their use as lipoprotein(a)-reducing agents. Sponsorship: Supported by the Netherlands Heart Foundation through grant No. 900-562-091 of the Netherlands Organization of Scientific Research (NWO), plus supplemental funding by the Institute for Scientific Information on Coffee. Descriptors: cafestol; experiment; human; kahweol; lipid metabolism; liver |
| وصف الملف: | application/octet-stream; application/pdf |
| تدمد: | 1476-5640 0954-3007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbfa2182ce697ab70ff53dca4c5f97a https://doi.org/10.1038/sj.ejcn.1600414 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3bbfa2182ce697ab70ff53dca4c5f97a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765640 09543007 |
|---|