Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats
| العنوان: | Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats |
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| المؤلفون: | Delfina Mercedes Romero, Carla Solange Sosa Holt, Gloria Álvarez, Marcelo Javier Wolansky, Mónica Elizabeth Mosquera Ortega, Alejandro Martín Pato, Adriana S. Ridolfi, Edda C. Villaamil Lepori |
| المصدر: | Toxicological Sciences. 172:225-234 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cyclopropanes, Male, Aging, Hydrocarbons, Fluorinated, Tefluthrin, Bifenthrin, Administration, Oral, Pharmacology, Toxicology, Body Temperature, chemistry.chemical_compound, Cerebellum, Pyrethrins, Animals, Potency, Distribution (pharmacology), Tissue Distribution, Dosing, Rats, Wistar, Pyrethroid, Dose-Response Relationship, Drug, fungi, Rats, Toxicokinetics, Liver, chemistry, Toxicity, Corn oil |
| الوصف: | Most pyrethroid insecticides (PYRs) share a similar primary target site in mammals. However, the potency estimates of the lethal and sublethal effects of these compounds differ up to 103-fold. The aim of this study was to evaluate the relationship between the dose administered, the target tissue dose, and the effect of 2 highly toxic PYRs, tefluthrin (TEF; 0.1–9 mg/kg) and bifenthrin (BIF; 0.5–12 mg/kg), by using the oral route, a corn oil vehicle (1 ml/kg) and subcutaneous temperature (Tsc) monitoring assays in adult rats. The Tsc was determined at 30-min intervals for 5 h (TEF) or 4.5 h (BIF) after dosing. Rats were sacrificed at 6 h after dosing, and BIF and TEF concentrations were determined in blood (Bd), liver (Lv), and cerebellum (Cb) by using a GC-ECD system. The minimal effective dose of BIF (3 mg/kg) affecting Tsc was similar to that found in prior studies using other testing paradigms. Regarding TEF, a very steep relationship between the dose administered and toxicity was observed, with a near-threshold to low-effective range for Tsc at 0.1–6 mg/kg, and a near lethal syndrome at ≥ 7.5 mg/kg. At 6–7.5 mg/kg TEF, the Cb/Bd and Cb/Lv concentration ratios were both > 1. Conversely, for BIF, the Cb concentration was barely over the Bd concentration and the Cb/Lv concentration ratio remained < 1. Our results and previous findings call for more comprehensive consideration to establish the relevance of the distribution into target tissues and the tissue dosimetry for health risks through the exposure to PYRs in humans. |
| تدمد: | 1096-0929 1096-6080 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd98be4da60b250ac105e998db5e487 https://doi.org/10.1093/toxsci/kfz204 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3bd98be4da60b250ac105e998db5e487 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10960929 10966080 |
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