Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients with Ankle Osteoarthritis
| العنوان: | Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients with Ankle Osteoarthritis |
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| المؤلفون: | Gino M. M. J. Kerkhoffs, Robert-Jan de Vos, Liam D. A. Paget, Adam Weir, Sjoerd A.S. Stufkens, Sita M A Bierma-Zeinstra, Gustaaf Reurink, Johannes L. Tol, Maarten H. Moen |
| المساهمون: | Orthopedic Surgery and Sports Medicine, AMS - Amsterdam Movement Sciences, Graduate School, AMS - Sports, AMS - Musculoskeletal Health, AMS - Ageing & Vitality, Orthopedics and Sports Medicine, General Practice |
| المصدر: | JAMA-Journal of the American Medical Association, 326(16), 1595-1605. American Medical Association Paget, L D A, Reurink, G, de Vos, R-J, Weir, A, Moen, M H, Bierma-Zeinstra, S M A, Stufkens, S A S, Kerkhoffs, G M M J & Tol, J L 2021, ' Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients with Ankle Osteoarthritis : A Randomized Clinical Trial ', JAMA-Journal of the American Medical Association, vol. 326, no. 16, pp. 1595-1605 . https://doi.org/10.1001/jama.2021.16602 JAMA |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Visual analogue scale, business.industry, Minimal clinically important difference, General Medicine, Osteoarthritis, Placebo, medicine.disease, law.invention, Clinical trial, medicine.anatomical_structure, Randomized controlled trial, law, Internal medicine, Orthopedic surgery, medicine, Ankle, business, Original Investigation |
| الوصف: | Importance: Approximately 3.4% of adults have ankle (tibiotalar) osteoarthritis and, among younger patients, ankle osteoarthritis is more common than knee and hip osteoarthritis. Few effective nonsurgical interventions exist, but platelet-rich plasma (PRP) injections are widely used, with some evidence of efficacy in knee osteoarthritis. Objective: To determine the effect of PRP injections on symptoms and function in patients with ankle osteoarthritis. Design, Setting, and Participants: A multicenter, block-randomized, double-blinded, placebo-controlled clinical trial performed at 6 sites in the Netherlands that included 100 patients with pain greater than 40 on a visual analog scale (range, 0-100) and tibiotalar joint space narrowing. Enrollment began on August 24, 2018, and follow-up was completed on December 3, 2020. Interventions: Patients were randomly assigned (1:1) to receive 2 ultrasonography-guided intra-articular injections of either PRP (n = 48) or placebo (saline; n = 52). Main Outcomes and Measures: The primary outcome was the validated American Orthopaedic Foot and Ankle Society score (range, 0-100; higher scores indicate less pain and better function; minimal clinically important difference, 12 points) over 26 weeks. Results: Among 100 randomized patients (mean age, 56 years; 45 [45%] women), no patients were lost to follow-up for the primary outcome. Compared with baseline values, the mean American Orthopaedic Foot and Ankle Society score improved by 10 points in the PRP group (from 63 to 73 points [95% CI, 6-14]; P |
| اللغة: | English |
| تدمد: | 0098-7484 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf049bda45cdcb5c7e56b3185498245 https://doi.org/10.1001/jama.2021.16602 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3bf049bda45cdcb5c7e56b3185498245 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00987484 |
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