Atopic dermatitis and risk of major neuropsychiatric disorders in children: A population‐based cohort study
| العنوان: | Atopic dermatitis and risk of major neuropsychiatric disorders in children: A population‐based cohort study |
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| المؤلفون: | Joy Wan, Daniel B. Shin, Maha N. Syed, Katrina Abuabara, Adina R. Lemeshow, Joel M. Gelfand |
| المصدر: | Journal of the European Academy of Dermatology and Venereology. 37:114-122 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Infectious Diseases, Dermatology |
| الوصف: | Paediatric atopic dermatitis (AD) has been linked to neuropsychiatric comorbidities such as depression, anxiety and attention-deficit/hyperactivity disorder (ADHD). However, longitudinal data are limited, and the effect of AD severity on neuropsychiatric outcomes requires further characterization.To determine the risk of several major neuropsychiatric conditions in children with AD.We analysed UK health records data in a population-based cohort study. Each patient18 years old with AD was matched to up to five unaffected patients on age, practice and index date. Treatments served as proxies for AD severity, which was analysed in a time-updated manner. Outcomes were incident anxiety, depression, bipolar disorder, schizophrenia, ADHD, autism, obsessive-compulsive disorder (OCD), suicidal ideation or attempt, and completed suicide.A total of 409,431 children with AD (93.2% mild, 5.5% moderate, 1.3% severe) were compared to 1,809,029 children without AD. In Cox regression models adjusted for age, sex, socioeconomic status and other atopic comorbidities, no statistically significant relationships were observed between AD and incident anxiety (HR 1.01, 95% CI 0.99-1.03), ADHD (1.02, 0.97-1.06), autism (1.02, 0.98-1.06), bipolar disorder (1.08, 0.85-1.36), suicidal ideation/attempt (0.98, 0.95-1.01) or completed suicide (0.85, 0.64-1.14). Children with AD were less likely to develop depression (0.93, 0.91-0.95) or schizophrenia (0.72, 0.54-0.95) but more likely to develop OCD (1.26, 1.16-1.37). However, there was substantial variation by AD severity and age in both the direction and magnitude of effect for many of the neuropsychiatric conditions examined.The was no substantial impact of AD on the overall risk of many neuropsychiatric conditions in children, but disease severity and age may be important modifying factors. Additional research is needed to further dissect the complex relationship between paediatric AD and neuropsychiatric comorbidities. |
| تدمد: | 1468-3083 0926-9959 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c54085fa79f0766c9166ab891446a46 https://doi.org/10.1111/jdv.18564 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3c54085fa79f0766c9166ab891446a46 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683083 09269959 |
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