Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels
| العنوان: | Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels |
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| المؤلفون: | Bansy Patel, Devang Sheth, Amit Vyas, Sunny Shah, Sachin Parmar, Chirag Patel, Sandip Patel, Jayesh Beladiya, Sonal Pande, Ketan Modi |
| المصدر: | Metabolic Brain Disease. 37:2533-2543 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Inflammation, Dipeptidyl-Peptidase IV Inhibitors, Memory Disorders, Tumor Necrosis Factor-alpha, Plant Extracts, Congo Red, Biochemistry, Streptozocin, Rats, Disease Models, Animal, Cellular and Molecular Neuroscience, Alzheimer Disease, Glucagon-Like Peptide 1, Ocimum sanctum, Animals, Cognitive Dysfunction, Neurology (clinical), Rats, Wistar, Maze Learning |
| الوصف: | DPP-4 inhibitors have been shown to reverse amyloid deposition in Alzheimer's disease (AD) patients with cognitive impairment. Ocimum sanctum L. leaves reported the presence of important phytoconstituents which are reported to have DPP-4 inhibitory activity. To investigate the effects of petroleum ether extract of Ocimum sanctum L. (PEOS) in Intracerebroventricular streptozotocin (ICV-STZ) induced AD rats. ICV-STZ (3 mg/kg) was injected bilaterally into male Wistar rats, while sham animals received the artificial CSF. The ICV-STZ-induced rats were administered with three doses of PEOS (100, 200, and 400 mg/kg, p.o.) for thirty days. All experimental rats were subjected to behaviour parameters (radial arm maze task and novel object recognition test), neurochemical parameters such as GLP-1, Aβ42, and TNF-α levels, and histopathological examination (Congo red staining) of the left brain hemisphere. PEOS significantly reversed the spatial learning and memory deficit exhibited by ICV-STZ-induced rats. Furthermore, PEOS also shows promising results in retreating Aβ deposition, TNF α, and increasing GLP-1 levels. The histopathological study also showed a significant dose-dependent reduction in amyloid plaque formation and dense granule in PEOS -treated rats as compared to the ICV-STZ induced rats (Negative control). The results show that extract of Ocimum sanctum L. attenuated ICV-STZ-induced learning and memory deficits in rats and has the potential to be employed in the therapy of AD. |
| تدمد: | 1573-7365 0885-7490 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7679aec82ca405fc6df6a20e44b696 https://doi.org/10.1007/s11011-022-01056-8 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3c7679aec82ca405fc6df6a20e44b696 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737365 08857490 |
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