Pharmacokinetics of Human Growth Hormone Administered Subcutaneously with two Different Injection Systems
| العنوان: | Pharmacokinetics of Human Growth Hormone Administered Subcutaneously with two Different Injection Systems |
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| المؤلفون: | Stephan de la Motte, Francisco Harrison, Toby King, Joachim Klinger, Gunther Kefer |
| المصدر: | Arzneimittelforschung. 51:613-617 |
| بيانات النشر: | Georg Thieme Verlag KG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Cross-Over Studies, business.industry, Injections, Subcutaneous, Half-life, Absorption (skin), Models, Biological, Crossover study, Cannula, Bioavailability, Somatropin, Endocrinology, medicine.anatomical_structure, Pharmacokinetics, Area Under Curve, Growth Hormone, Internal medicine, Drug Discovery, medicine, Humans, business, Half-Life, Subcutaneous tissue |
| الوصف: | The bioavailability of recombinant human growth hormone (somatropin, CAS 12629-01-5) was compared between a transcutaneous jet injection device and subcutaneous cannula injection. Thirteen healthy male subjects received 8.64 IU somatropin once with jet and once with cannula injection in a randomized cross-over study. Baseline-corrected somatropin serum concentrations were evaluated with non-compartmental and compartmental methods. The 90% confidence intervals with two one-sided t-tests around the ratios of injection devices were 91-120% for maximum concentration, 94-110% for area-under-curve until 14 h, and 92-103% for area-under-curve to infinity. Somatropin has a known metabolic half-life of ca. 20-30 min while the observed terminal half-lives were 2-4 h. Absorption and elimination rate constants were similar. Times of maximum concentrations, terminal half-lives and lag times to start of absorption appeared to be shorter and the absorption rate constant appeared to be larger for jet than for cannula injection. In conclusion, the kinetics of somatropin from subcutaneous tissue had a "flip-flop" characteristic. Bioavailability of somatropin after jet injection was equivalent to cannula injection. |
| تدمد: | 1616-7066 0004-4172 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c91e2fff0b581ae5e0fd3bc8671103b https://doi.org/10.1055/s-0031-1300089 |
| رقم الأكسشن: | edsair.doi.dedup.....3c91e2fff0b581ae5e0fd3bc8671103b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16167066 00044172 |
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