Highly Cytotoxic Metabolites from the Culture Supernatant of the Temperate Dinoflagellate Protoceratium cf. reticulatum
| العنوان: | Highly Cytotoxic Metabolites from the Culture Supernatant of the Temperate Dinoflagellate Protoceratium cf. reticulatum |
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| المؤلفون: | Xuemin Yang, Yuzuru Shimizu, Masataka Konishi, Craig R. Fairchild, Bo Li |
| المصدر: | Journal of Natural Products. 67:1309-1313 |
| بيانات النشر: | American Chemical Society (ACS), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Oceans and Seas, Metabolite, Pharmaceutical Science, Antineoplastic Agents, medicine.disease_cause, Analytical Chemistry, chemistry.chemical_compound, Ethers, Cyclic, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Glycosides, Cytotoxicity, Pharmacology, chemistry.chemical_classification, biology, Toxin, Oxocins, Organic Chemistry, Dinoflagellate, Glycoside, Biological activity, biology.organism_classification, Complementary and alternative medicine, Biochemistry, chemistry, Cell culture, Dinoflagellida, Molecular Medicine, Marine Toxins, Drug Screening Assays, Antitumor, Marine toxin |
| الوصف: | In the course of our search for antitumor compounds in dinoflagellates, the culture broths of two strains of Protoceratium cf. reticulatum showed extremely potent cytotoxicity against human tumor cell lines. The four equally active principles, named protoceratins I (1), II (2), III (3), and IV (4), were purified and their structures were studied. The major principle, protoceratin I (1), proved to be identical with 2-homoyessotoxin, a well-known shellfish toxin. Protoceratins II (2), III (3), and IV (4) were determined to be di-, mono-, and triarabinoside of 1, respectively. They are the first examples of glycosides of dinoflagellate polyethers. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9862227cb80095a1a897acfe95b86a https://doi.org/10.1021/np040008c |
| رقم الأكسشن: | edsair.doi.dedup.....3c9862227cb80095a1a897acfe95b86a |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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