In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers
| العنوان: | In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers |
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| المؤلفون: | Maciej Guzik, Wojciech Snoch, Dawid Wnuk, Tomasz Witko, Francisco J. Plou, Jakub Staroń, Andrzej J. Bojarski, Ewelina Jarek |
| المصدر: | International Journal of Molecular Sciences Volume 22 Issue 13 International Journal of Molecular Sciences, Vol 22, Iss 7238, p 7238 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, sugar esters, Intermediate Filaments, 02 engineering and technology, Metastasis, 0302 clinical medicine, Cell Movement, Drug Discovery, Biology (General), Cytotoxicity, Spectroscopy, chemistry.chemical_classification, Esters, General Medicine, 021001 nanoscience & nanotechnology, prostate cancer, Computer Science Applications, Chemistry, Biochemistry, 030220 oncology & carcinogenesis, Female, 0210 nano-technology, QH301-705.5, Antineoplastic Agents, Article, Catalysis, Polyhydroxyalkanoates, Inorganic Chemistry, Structure-Activity Relationship, 03 medical and health sciences, anticancer agents, Cell Line, Tumor, medicine, melanoma, Humans, MTT assay, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Cell Proliferation, Organic Chemistry, polyhydroxyalkanoates, chemical modifications, Fatty acid, Cancer, medicine.disease, fluorination, Enzyme, chemistry, Cancer cell, Drug Screening Assays, Antitumor, Sugars |
| الوصف: | [EN] Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE's hydrophobic chains can influence their cytotoxicity against human skin melanoma and prostate cancer cell lines. The compound's cytotoxicity was determined by an MTT assay, which followed an assessment of SFAEs' potential metastatic properties in concentrations below IC50 values. Despite relatively high IC50 values (63.3-1737.6 μM) of the newly synthesized SFAE, they can compete with other sugar esters already described in the literature. The chosen bioactives caused low polymerization of microtubules and the depolymerization of actin filaments in nontoxic levels, which suggest an apoptotic rather than metastatic process. Altogether, cancer cells showed no propensity for metastasis after treating them with SFAE. They confirmed that lactose-based compounds seem the most promising surfactants among tested sugar esters. This manuscript creates a benchmark for creation of novel anticancer agents based on 3-hydroxylated fatty acids of bacterial origin. Wojciech Snoch acknowledges the support of InterDokMed project no. POWR.03.02.00-00-I013/16. We greatly acknowledge the joint consortium “Interdisciplinary Centre of Physical, Chemical and Biological Sciences” of ICSC PAS and INP PAS for providing access to the Agilent 1290 Infinity System with an automatic autosampler and an MS Agilent 6460 Triple Quad Detector. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms22137238 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9b2662695ac29000d7d586cbe0e2bf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3c9b2662695ac29000d7d586cbe0e2bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms22137238 |