Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes
| العنوان: | Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes |
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| المؤلفون: | Dexin Zhang, Lulin Ma, Zhi Xiao, Juan Li, Ying Li, Junli Zhou, Song Cao, Tian Yu |
| المصدر: | iScience, Vol 24, Iss 2, Pp 102108-(2021) iScience |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Elevated plus maze, Immunology, Hippocampus, 02 engineering and technology, Pharmacology, Article, Open field, 03 medical and health sciences, Medicine, Prefrontal cortex, lcsh:Science, Neuroinflammation, Multidisciplinary, Microglia, business.industry, 021001 nanoscience & nanotechnology, Tail suspension test, 030104 developmental biology, medicine.anatomical_structure, nervous system, lcsh:Q, Cellular Physiology, 0210 nano-technology, business, Astrocyte, Neuroscience |
| الوصف: | Summary This study aimed to explore the effects and possible mechanisms of intravenous lidocaine in postherpetic neuralgia (PHN) rats. Mechanical withdrawal thresholds and thermal withdrawal latencies were measured. Open field test, elevated plus maze test, and tail suspension test were used to assess anxiety- and depressive-like behaviors. Microglia and astrocytes in spinal dorsal horn (SDH), prefrontal cortex (PFC), anterior cingulate cortex (ACC), and hippocampus were analyzed. The expression of TNF-α, IL-1β, and IL-4 in SDH and serum were evaluated. Intravenous lidocaine alleviated mechanical allodynia and thermal hypoalgesia, downregulated the expression of TNF-α and IL-1β, and inhibited the activation of microglia and astrocytes in SDH. In addition, it reduced the activation of astrocyte but not microglia in PFC, ACC, and hippocampus. Intravenous lidocaine may relieve PHN by inhibiting the activation of microglia and astrocyte in SDH or by reducing the neuroinflammation and astrocyte activation in PFC, ACC, and hippocampus. Graphical Abstract Highlights • Intravenous lidocaine alleviates PHN in rats • Intravenous lidocaine inhibits microglia and astrocyte activation • Intravenous lidocaine cannot relieve anxiety and depression in PHN rats Cellular Physiology; Immunology; Neuroscience |
| اللغة: | English |
| تدمد: | 2589-0042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb80d505fe307e66d40af9c1bd18ac0 http://www.sciencedirect.com/science/article/pii/S2589004221000766 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3cb80d505fe307e66d40af9c1bd18ac0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25890042 |
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