Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery
| العنوان: | Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery |
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| المؤلفون: | Douglas A. Pippin, Torsten Herbertz, Joseph M. Salvino, Arup K. Ghose, John P. Mallamo |
| المصدر: | Journal of Medicinal Chemistry. 51:5149-5171 |
| بيانات النشر: | American Chemical Society (ACS), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Drug, media_common.quotation_subject, Quantitative Structure-Activity Relationship, Pharmacology, Ligands, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Databases, Protein, Benzamide, Phosphorylase kinase, Protein Kinase Inhibitors, media_common, Binding Sites, biology, Chemistry, Drug discovery, Kinase, Imatinib, Biochemistry, Drug Design, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Signal transduction, medicine.drug |
| الوصف: | toward kinase inhibitor discovery, with the result that several kinase inhibitors have been approved as drugs since 2001. The commercial success of imatinib (N-(4-methyl-3-(4-(pyridin-3yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-l)methyl)benzamide) has provided a clear incentive for the continued pursuit of kinase inhibitor design. |
| تدمد: | 1520-4804 0022-2623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfdacb02a80ba9f72c931b97abe0190 https://doi.org/10.1021/jm800475y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3cfdacb02a80ba9f72c931b97abe0190 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204804 00222623 |
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