Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T
| العنوان: | Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T |
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| المؤلفون: | Lin Chen, Xiongqi Han, Kannie W. Y. Chan, Xiang Xu, Jiadi Xu, Jianpan Huang |
| المصدر: | Magnetic Resonance in Medicine. 85:254-267 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Materials science, biology, Phantoms, Imaging, Brain, Proteins, Pulse duration, Field strength, Magnetic Resonance Imaging, Imaging phantom, 030218 nuclear medicine & medical imaging, Mice, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, Image Interpretation, Computer-Assisted, biology.protein, Animals, Pulse wave, Radiology, Nuclear Medicine and imaging, Magnetization transfer, Bovine serum albumin, Pulse number, Saturation (magnetic), 030217 neurology & neurosurgery |
| الوصف: | Purpose To develop a pulsed CEST magnetization-transfer method for rapidly acquiring relayed nuclear Overhauser enhancement (rNOE)-weighted images with magnetic transfer contrast (MTC) suppression at clinical field strength (3 T). Methods Using a pulsed CEST magnetization-transfer method with low saturation powers (B1 ) and long mixing time (tmix ) to suppress contributions due to strong MTC from solid-like macromolecules, a low B1 also minimized direct water saturation. These MTC contributions were further reduced by subtracting the Z-spectral signals at two or three offsets by assuming that the residual MTC is a linear function between -3.5 ppm and -12.5 ppm. Results Phantom studies of a lactic acid (Lac) solution mixed with cross-linked bovine serum albumin show that strong MTC interference has a significant impact on the optimum B1 for detecting rNOEs, due to lactate binding. The MTC could be effectively suppressed using a pulse train with a B1 of 0.8 μT, a pulse duration (tp ) of 40 ms, a tmix of 60 ms, and a pulse number (N) of 30, while rNOE signal was well maintained. As a proof of concept, we applied the method in mouse brain with injected hydrogel and a cell-hydrogel phantom. Results showed that rNOE-weighted images could provide good contrast between brain/cell and hydrogel. Conclusion The developed pulsed CEST magnetization-transfer method can achieve MTC suppression while preserving most of the rNOE signal at 3 T, which indicates the potential for translation of this technique to clinical applications related to mobile proteins/lipids change. |
| تدمد: | 1522-2594 0740-3194 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d442e832950d6a43597a5c1540ff580 https://doi.org/10.1002/mrm.28433 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3d442e832950d6a43597a5c1540ff580 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222594 07403194 |
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