Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
| العنوان: | Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism |
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| المؤلفون: | Helen Budge, James Law, José Joaquín Muros, Ellie Finn, David E. Morris, Lindsay Robinson, Louise Denvir, Valerie Astle, Michael E. Symonds, Tabitha Randell |
| المصدر: | Journal of the Endocrine Society Digibug. Repositorio Institucional de la Universidad de Granada instname |
| بيانات النشر: | Endocrine Society, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Autoimmune hypothyroidism, medicine.medical_specialty, Cold stimulation, endocrine system, endocrine system diseases, Thyroid hormones, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Stimulation, Brown adipose tissue, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Euthyroid, Clinical Research Articles, Increased TSH, thyroid hormones, Obesity and Adipocyte Biology, business.industry, Thyroid, autoimmune, brown adipose tissue, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Cold-induced thermogenesis, infrared thermography, Infrared thermography, hypothyroidism, BAT activity, business, Autoimmune, cold-induced thermogenesis |
| الوصف: | The interaction between thyroid status and brown adipose tissue (BAT) activation is complex. We assessed the effect of autoimmune hypothyroidism (ATD) in female children on BAT activation, measured using infrared thermography. Participants with ATD had lower resting (hypothyroid, 34.9 +- 0.7°C; control, 35.4 +- 0.5°C; P = 0.03) and stimulated (hypothyroid, 35.0 +- 0.6°C; control, 35.5 +- 0.5°C; P = 0.04) supraclavicular temperatures compared with controls, but there was no difference between groups in the temperature increase with stimulation. BAT activation, calculated as the relative temperature change comparing the supraclavicular temperature to a sternal reference region, was reduced in participants with ATD (hypothyroid, 0.1 +- 0.1°C; control, 0.2 +- 0.2°C; P = 0.04). Children with ATD were frequently biochemically euthyroid due to replacement therapy, but, despite this, increased relative supraclavicular temperature was closely associated with increased TSH (r = 0.7, P = 0.01) concentrations. Girls with ATD had an attenuated thermogenic response to cold stimulation compared with healthy controls, but, contrary to expectation, those with suboptimal biochemical control (with higher TSH) showed increased BAT activation. This suggests that the underlying disease process may have a negative effect on BAT response, but high levels of TSH can mitigate, and even stimulate, BAT activity. In summary, thyroid status is a complex determinant of BAT activity in girls with ATD. This work was supported by a pump-priming grant from Nottingham University Hospitals Charity (Grant PP-Law-Nov12). |
| اللغة: | English |
| تدمد: | 2472-1972 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d552c1b383e3270f1d6183968a88f0e http://europepmc.org/articles/PMC6872489 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3d552c1b383e3270f1d6183968a88f0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24721972 |
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