Pre-operative chronic opioid or glucocorticoid use and mortality after noncardiac surgery
| العنوان: | Pre-operative chronic opioid or glucocorticoid use and mortality after noncardiac surgery |
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| المؤلفون: | Young-Tae Jeon, Tak Kyu Oh, Saeyeon Kim, In-Ae Song |
| المصدر: | European Journal of Anaesthesiology. 37:926-933 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Population, MEDLINE, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Internal medicine, medicine, Humans, education, Glucocorticoids, Retrospective Studies, education.field_of_study, business.industry, 030208 emergency & critical care medicine, Retrospective cohort study, Confidence interval, Analgesics, Opioid, Anesthesiology and Pain Medicine, Opioid, Elective Surgical Procedures, business, Noncardiac surgery, Glucocorticoid, Cohort study, medicine.drug |
| الوصف: | BACKGROUND The chronic use of opioids and glucocorticoids is associated with serious side effects. Moreover, both medications are related to poor long-term postoperative outcomes. OBJECTIVE The study aimed to investigate the association between pre-operative chronic opioid and glucocorticoid use and 90-day mortality after noncardiac surgery. DESIGN Retrospective, population-based cohort study. SETTING Single tertiary academic hospital. PATIENTS The study enrolled adult (≥18 years of age) patients admitted to Seoul National University Bundang Hospital, between January 2012 and December 2018 for planned, elective, noncardiac surgery. MAIN OUTCOME MEASURES The study compared the 90-day mortality for patients using opioids or glucocorticoids chronically (≥3 months) prior to surgery and for opioid-naive and glucocorticoid-naive patients. RESULTS A total of 112 606 patients were included in the study. Among them, 107 843 (95.9%) were opioid-naive and glucocorticoid-naive patients; 3373 (3.0%), 1199 (1.1%) and 191 patients (0.2%) were chronic users of opioids, glucocorticoids or both, respectively. In the multivariable model, compared with opioid-naive and glucocorticoid-naive patients, the odds of dying within 90 days were significantly higher for chronic users of opioids [3.56-fold; 95% confidence intervals (CIs) 2.36 to 5.38; P |
| تدمد: | 1365-2346 0265-0215 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d58a1e2c2de129670a45cda8b537ce0 https://doi.org/10.1097/eja.0000000000001212 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3d58a1e2c2de129670a45cda8b537ce0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652346 02650215 |
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