Propranolol in the treatment of infantile haemangiomas: lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce survey
| العنوان: | Propranolol in the treatment of infantile haemangiomas: lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce survey |
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| المؤلفون: | S Baryschpolec, S. Darne, T McPherson, K Bhate, Grainne M. O'Regan, R. M. Ross Hearn, J Halpern, Annalisa Patrizi, J V Bjerre, N. Goldstraw, J Thomson, L Shaw, R Jayaraj, Eulalia Baselga, P.H. Hoeger, M. Glover, Arnold P. Oranje, A Hernandez-Martin, Timothy H Clayton, M Tsakok, B. Laguda, L Hedelund, Åke Svensson, Carsten Flohr, Jane Ravenscroft, R Taylor, Sara J. Brown, Regina Foelster-Holst, Isabella Neri, Nigel Burrows, D Morrison, Veronika Dvorakova, E Wedgeworth, T Schill, P Tiffin, A. Durack, Alan D. Irvine, S. Leech, S Hoey, Aileen Taylor, S. Grabczynska, B Hughes, L Solman, R Ramesh, Carl-Fredrik Wahlgren, David J. Greenblatt, H Audrain, M Lam, E K Johansson, H. Shahidullah, P.E. Beattie, Sherief R. Janmohamed, W Porter, J. E. Gach, H Goodyear |
| المساهمون: | Wedgeworth, E., Glover, M., Irvine, A.D., Neri, I., Baselga, E., Clayton, T.H., Beattie, P.E., Bjerre, J.V., Burrows, N.P., Foelster-Holst, R., Hedelund, L., Hernandez-Martin, A., Audrain, H., Bhate, K., Brown, S.J., Baryschpolec, S., Darne, S., Durack, A., Dvorakova, V., Gach, J., Goldstraw, N., Goodyear, H., Grabczynska, S., Greenblatt, D., Halpern, J., Hearn, R.M.R., Hoey, S., Hughes, B., Jayaraj, R., Johansson, E.K., Lam, M., Leech, S., O'Regan, G.M., Morrison, D., Porter, W., Ramesh, R., Schill, T., Shaw, L., Taylor, A.E.M., Taylor, R., Thomson, J., Tiffin, P., Tsakok, M., Janmohamed, S.R., Laguda, B., Mcpherson, T., Oranje, A.P., Patrizi, A., Ravenscroft, J.C., Shahidullah, H., Solman, L., Svensson, A., Wahlgren, C.F., Hoeger, P.H., Flohr, C, Faculty of Medicine and Pharmacy, Skin function and permeability, Surgical clinical sciences, Dermatology |
| المصدر: | Wedgeworth, E, Glover, M, Irvine, A D, Neri, I, Baselga Torres, E, Clayton, T H, Beattie, P E, Bjerre, J V, Burrows, N P, Foelster-Holst, R, Hedelund, L, Hernandez-Martin, A, Audrain, H, Bhate, K, Brown, S J, Baryschpolec, S, Darne, S, Durack, A, Dvorakova, V, Gach, J, Goldstraw, N, Goodyear, H, Grabcyznska, S, Greenblatt, D, Halpern, J, Hearn, R M R, Hoey, S, Hughes, B, Jayaraj, R, Johansson, E K, Lam, M, Leech, S, O'Regan, G M, Morrison, D, Porter, W, Ramesh, R, Schill, T, Shaw, L, Taylor, A E M, Taylor, R, Thomson, J, Tiffin, P, Tsakok, M, Janmohamed, S R, Laguda, B, McPherson, T, Oranje, A, Patrizi, A, Ravenscroft, J, Shahidullah, H, Soloman, L, Svensson, A, Wahlgren, C F, Hoeger, P H & Flohr, C 2015, ' Propranolol in the treatment of infantile haemangiomas : Lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce Survey ', British Journal of Dermatology, vol. 174, pp. 594-601 . https://doi.org/10.1111/bjd.14233 BRITISH JOURNAL OF DERMATOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Skin Neoplasms, Treatment outcome, Administration, Oral, Antineoplastic Agents, Dermatology, Propranolol, Hemangioma, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Skin Neoplasms/drug therapy, Medicine, Humans, Dose-Response Relationship, Drug, Hemangioma/drug therapy, business.industry, Infant, medicine.disease, Antineoplastic Agents/administration & dosage, body regions, First line treatment, Treatment Outcome, Multicenter study, Female, Propranolol/administration & dosage, business, medicine.drug |
| الوصف: | Summary Background Oral propranolol is widely prescribed as first-line treatment for infantile haemangiomas (IHs). Anecdotally, prescribing practice differs widely between centres. Objectives The Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce was founded to establish patterns of use of propranolol in IHs. Methods Participating centres entered data on all of their patients who had completed treatment with oral propranolol for IHs, using an online data capture tool. Results The study cohort comprised 1097 children from 39 centres in eight European countries. 76·1% were female and 92·8% had a focal IH, with the remainder showing a segmental, multifocal or indeterminate pattern. The main indications for treatment were periocular location (29·3%), risk of cosmetic disfigurement (21·1%) and ulceration and bleeding (20·6%). In total 69·2% of patients were titrated up to a maintenance regimen, which consisted of 2 mg kg−1 per day (85·8%) in the majority of cases. 91·4% of patients had an excellent or good response to treatment. Rebound growth occurred in 14·1% upon stopping, of whom 53·9% were restarted and treatment response was recaptured in 91·6% of cases. While there was no significant difference in the treatment response, comparing a daily maintenance dose of < 2 mg kg−1 vs. 2 mg kg−1 vs. > 2 mg kg−1, the risk of adverse events was significantly higher: odds ratio (OR) 1 vs. adjusted OR 0·70, 95% confidence interval (CI) 0·33–1·50, P = 0·36 vs. OR 2·38, 95% CI 1·04–5·46, P = 0·04, Ptrend < 0·001. Conclusions The PITCH survey summarizes the use of oral propranolol across 39 European centres, in a variety of IH phases, and could be used to inform treatment guidelines and the design of an interventional study. |
| وصف الملف: | STAMPA |
| تدمد: | 1365-2133 0007-0963 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6bc3940ce47d9b74060c89d5738a30 https://pubmed.ncbi.nlm.nih.gov/26473312 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3d6bc3940ce47d9b74060c89d5738a30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652133 00070963 |
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