التفاصيل البيبلوغرافية
| العنوان: |
Gastrointestinal Symptoms and Channelopathy-Associated Epilepsy |
| المؤلفون: |
Anne T. Berg, Lori L. Isom, Veronica C. Beck |
| المصدر: |
J Pediatr |
| بيانات النشر: |
Elsevier BV, 2021. |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Genetic Markers, Male, medicine.medical_specialty, Constipation, Adolescent, Gastrointestinal Diseases, media_common.quotation_subject, medicine.medical_treatment, Logistic regression, Severity of Illness Index, Article, Epilepsy, Shab Potassium Channels, Channelopathy, Risk Factors, Internal medicine, Prevalence, medicine, Humans, KCNQ2 Potassium Channel, Child, Gastrointestinal dysmotility, media_common, Brain Diseases, business.industry, Infant, Appetite, medicine.disease, Health Surveys, NAV1.1 Voltage-Gated Sodium Channel, Logistic Models, Autism spectrum disorder, Child, Preschool, Pediatrics, Perinatology and Child Health, Channelopathies, Female, medicine.symptom, business, Ketogenic diet |
| الوصف: |
OBJECTIVE: To determine the prevalence of and identify factors associated with gastrointestinal (GI) symptoms among patients with channelopathy-associated developmental and epileptic encephalopathy (DEE). STUDY DESIGN: Parents of 168 patients with DEEs linked to SCN1A (N=59), KCNB1 (N=31), or KCNQ2 (N=78) completed online CLIRINX© surveys about their children’s GI symptoms. Analysis examined prevalence, frequency, and severity of GI symptoms, as well as DEE type, functional mobility, feeding difficulties, ketogenic diet, anti-seizure medication, autism spectrum disorder (ASD), and seizures. Statistical analyses included chi-square tests, Wilcoxon rank-sum analyses, and multiple logistic regression. RESULTS: GI symptoms were reported in 92/168 (55%) patients among whom 63/86 (73%) reported daily or weekly symptoms, 29/92 (32%) had frequent or serious discomfort, and 13/91 (14%) had frequent or serious appetite disturbances as a result. The prevalence of GI symptoms varied across DEE cohorts with 44% of SCN1A-DEE patients, 35% of KCNB1-DEE patients, and 71% of KCNQ2-DEE patients reporting GI symptoms in the previous month. After adjustment for DEE type, current use of ketogenic diet (6% reported), and gastrostomy tube (13% reported) were both associated with GI symptoms in a statistically, but not clinically significant manner (P < 0.05). Patient age, functional mobility, feeding difficulties, ASD, and seizures were not clearly associated with GI symptoms. Overall, no individual anti-seizure medication was significantly associated with GI symptoms across all DEE cohorts. CONCLUSIONS: GI symptoms are common and frequently severe in DEE patients. |
| تدمد: |
0022-3476 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da41df1a4b26bbce6424d578ad7a867
https://doi.org/10.1016/j.jpeds.2021.06.034 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....3da41df1a4b26bbce6424d578ad7a867 |
| قاعدة البيانات: |
OpenAIRE |
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