Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests
| العنوان: | Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests |
|---|---|
| المؤلفون: | Vania F. Prado, Ari L. Mendell, Bettina E. Kalisch, Neil J. MacLusky, Boyer D. Winters, Marco A. M. Prado, Samantha D. Creighton, Daniel Palmer |
| المصدر: | Anatomy and Cell Biology Publications Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | Scholarship@Western, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, genetic structures, media_common.quotation_subject, Transgene, lcsh:Medicine, Mice, Transgenic, Disease, Neuropsychological Tests, Spatial memory, Article, 03 medical and health sciences, Mice, Cell and Developmental Biology, 0302 clinical medicine, Alzheimer Disease, Perception, Animals, Cognitive Dysfunction, lcsh:Science, media_common, Multidisciplinary, Behavior, Animal, lcsh:R, Cognitive neuroscience of visual object recognition, Object based, Cognition, Object (computer science), Disease Models, Animal, 030104 developmental biology, lcsh:Q, Female, Anatomy, Psychology, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Object recognition tasks detect cognitive deficits in transgenic Alzheimer’s disease (AD) mouse models. Object recognition, however, is not a unitary process, and there are many uncharacterized facets of object processing with relevance to AD. We therefore systematically evaluated object processing in 5xFAD and 3xTG AD mice to clarify the nature of object recognition-related deficits. Twelve-month-old male and female 5xFAD and 3xTG mice were assessed on tasks for object identity recognition, spatial recognition, and multisensory object perception. Memory and multisensory perceptual impairments were observed, with interesting dissociations between transgenic AD strains and sex that paralleled neuropathological changes. Overreliance on the widespread “object recognition” task threatens to slow discovery of potentially significant and clinically relevant behavioural effects related to this multifaceted cognitive function. The current results support the use of carefully designed object-based test batteries to clarify the relationship between “object recognition” impairments and specific aspects of AD pathology in rodent models. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3daf6fcf137b961be0a7ab669b29a532 https://ir.lib.uwo.ca/anatomypub/171 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3daf6fcf137b961be0a7ab669b29a532 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |