Significance of Free to Total PSA Ratio in Men with Slightly Elevated Serum PSA Levels: A Cooperative Study
| العنوان: | Significance of Free to Total PSA Ratio in Men with Slightly Elevated Serum PSA Levels: A Cooperative Study |
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| المؤلفون: | Yoichi Arai, Shin Egawa, Hidetoshi Yamanaka, Kyoichi Imai, Manabu Kuriyama, Ken Koshiba, Yukimichi Kawada, Hiroshi Maeda |
| المصدر: | Japanese Journal of Clinical Oncology. 28:661-665 |
| بيانات النشر: | Oxford University Press (OUP), 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Male, Gynecology, Cancer Research, medicine.medical_specialty, business.industry, Free psa, Urology, Prostatic Neoplasms, Cancer, Diagnostic accuracy, General Medicine, Prostate-Specific Antigen, medicine.disease, Sensitivity and Specificity, Elevated serum, Prostate-specific antigen, Prostate cancer, Oncology, medicine, Humans, Radiology, Nuclear Medicine and imaging, Clinical significance, business, Total psa |
| الوصف: | Background: The ratio of free PSAin total PSA(fit) has been reported to improve the diagnostic accuracy of prostate cancer in the groupwith slightly elevated serum PSA values. In Japanese cases, the clinical significance of fit is still controversial. Methods: The diagnostic significance of fit in serum for prostate cancer was evaluated in a cooperative study. A total of 77 cases with prostate cancer and 224 with non-prostate cancer showing less than 20 ng/ml of total PSAwere evaluated. Results: Serum total and free PSA values were not affected by storage at 25°C for 2 days. The determination of fit was useful in the cases with a serum total PSA of 5.1-10 ng/ml; the specificity was 60% with a sensitivity of 90% at an fit of 0.148. The positive predictive value for diagnosis of prostate cancer also increased to 54%from 34% of that in total PSA alone. In the range of 4.1-10 ng/ml, the cut-off value of fit was 0.155 for obtaining relatively high specificity; sensitivity was 85% and specificity was 56.5%. Conclusions: Thus, thedetermination offit wasconsidered to beaneffective tool fordiscriminating the non-prostate cancer cases from those of prostate cancer. |
| تدمد: | 1465-3621 0368-2811 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dde60b3829773e380da29bc4809356e https://doi.org/10.1093/jjco/28.11.661 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3dde60b3829773e380da29bc4809356e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14653621 03682811 |
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