Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments
| العنوان: | Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments |
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| المؤلفون: | Francesco De Logu, Romina Nassini, Deborah Novelli, Marcello Trevisani, Silvia Cantoni, Fabrizio Facchinetti, Ilaria Russo, Lidia Staszewsky, Sabina Ceriani, Marco Milioli, Serge Masson, Francesca Fumagalli, Teresa Letizia, Monica Salio, Daria De Giorgio, Giuseppe Ristagno, Roberto Latini, Roberta Massafra, Davide Olivari |
| المصدر: | MethodsX, Vol 7, Iss, Pp 100771-(2020) MethodsX |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Randomization, Clinical Biochemistry, Disease, 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Dose finding, Right ventricular systolic pressure, Heart histology, Internal medicine, Medicine, lcsh:Science, Alanine transaminase, 030304 developmental biology, 0105 earth and related environmental sciences, ComputingMethodologies_COMPUTERGRAPHICS, Protocol (science), 0303 health sciences, Creatinine, Monocrotaline, business.industry, Sample size, Primary pulmonary arterial hypertension, Medicine and Dentistry, Morphometric analysis of pulmonary arteries, Medical Laboratory Technology, Cardiac biomarkers, Blood pressure, chemistry, Echocardiography, Cardiology, Ventricular pressure, lcsh:Q, business |
| الوصف: | Graphical abstract The identification of new treatments for primary pulmonary arterial hypertension (PAH) is a critical unmet need since there is no a definitive cure for this disease yet. Due to the complexity of PAH, a wide set of methods are necessary to assess the response to a pharmacological intervention. Thus, a rigorous protocol is crucial when experimental studies are designed. In the present experimental protocol, a stepwise approach was followed in a monocrotaline-induced PAH model in the rat, moving from the dose finding study of treatment compounds to the recognition of the onset of disease manifestation, in order to identify when to start a curative treatment. A complete multidimensional evaluation of treatment effects represented the last step. The primary study endpoint was the change in right ventricular systolic pressure after 14 days of treatment; echocardiographic and biohumoral markers together with heart and pulmonary arterial morphometric parameters were considered as secondary efficacy and/or safety endpoints and for the evaluation of the biologic coherence in the different results. |
| اللغة: | English |
| تدمد: | 2215-0161 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e143418789146b9edc0d59b447027d2 http://www.sciencedirect.com/science/article/pii/S2215016119303474 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3e143418789146b9edc0d59b447027d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22150161 |
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